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Provedor de dados:  BJMBR
País:  Brazil
Título:  Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
Autores:  Chen,Jie
Wu,Yu
Yu,Jiannong
Shen,Jinming
Data:  2018-01-01
Ano:  2018
Palavras-chave:  TNF-α
Osteoarthritis
Polymorphism
Meta-analysis
Resumo:  Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800604
Editor:  Associação Brasileira de Divulgação Científica
Relação:  10.1590/1414-431x20187311
Formato:  text/html
Fonte:  Brazilian Journal of Medical and Biological Research v.51 n.8 2018
Direitos:  info:eu-repo/semantics/openAccess
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