| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities
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| Autores: |
Petit,C.
Bernardes-Genisson,V.
Hoffmann,P.
Souchard,J.-P.
Labidalle,S.
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| Data: |
1999-11-01
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| Ano: |
1999
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| Palavras-chave: |
Nitric oxide
S-nitrosothiols (thionitrites)
Antioxidant
Peroxynitrite
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| Resumo: |
Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X1999001100011
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.32 n.11 1999
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| Direitos: |
info:eu-repo/semantics/openAccess
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