| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia
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| Autores: |
de Souza,H.M.
Borba-Murad,G.R.
Ceddia,R.B.
Curi,R.
Vardanega-Peicher,M.
Bazotte,R.B.
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| Data: |
2001-06-01
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| Ano: |
2001
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| Palavras-chave: |
Insulin-induced hypoglycemia
Hepatic glucose production
Gluconeogenesis
Alainne
Glutamine
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| Resumo: |
Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated. For this purpose, livers were perfused with a saturating concentration of 2 mM glycerol, 5 mM L-alanine or 5 mM L-glutamine as gluconeogenic substrates. All experiments were performed 1 h after an ip injection of saline (CN group) or 1 IU/kg of insulin (IN group). The IN group showed higher (P<0.05) hepatic glucose production from glycerol, L-alanine and L-glutamine and higher (P<0.05) production of L-lactate, pyruvate and urea from L-alanine and L-glutamine. In addition, ip injection of 100 mg/kg glycerol, L-alanine and L-glutamine promoted glucose recovery. The results indicate that the hepatic capacity to produce glucose from gluconeogenic precursors was increased during insulin-induced hypoglycemia.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600012
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/S0100-879X2001000600012
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.34 n.6 2001
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| Direitos: |
info:eu-repo/semantics/openAccess
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