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Provedor de dados:  BJM
País:  Brazil
Título:  Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins
Autores:  Sampaio,Jorge Luiz Mello
Gales,Ana Cristina
Data:  2016-12-01
Ano:  2016
Palavras-chave:  ESBL
KPC
NDM
Extended spectrum β-lactamases
New Delhi metallo-β-lactamase
Klebsiella pneumoniae carbapenemase
Polymyxin B
Colistin
Antimicrobial resistance
Carbapenemases
Brazil
Enterobacteriaceae
Resumo:  ABSTRACT During the last 30 years there has been a dissemination of plasmid-mediated β-lactamases in Enterobacteriaceae in Brazil. Extended spectrum β-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneumoniae is the predominant species among ESBL producers. Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae became widely disseminated in Brazil during the last decade and KPC production is currently the most frequent resistance mechanism (96.2%) in carbapenem resistant K. pneumoniae. To date KPC-2 is the only variant reported in Brazil. Polymyxin B resistance in KPC-2-producing K. pneumoniae has come to an alarming rate of 27.1% in 2015 in São Paulo, the largest city in Brazil. New Delhi metallo-β-lactamase was detected in Brazil in 2013, has been reported in different Brazilian states but are not widely disseminated. Antimicrobial resistance in Enterobacteriaceae in Brazil is a very serious problem that needs urgent actions which includes both more strict adherence to infection control measures and more judicious use of antimicrobials.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500031
Editor:  Sociedade Brasileira de Microbiologia
Relação:  10.1016/j.bjm.2016.10.002
Formato:  text/html
Fonte:  Brazilian Journal of Microbiology v.47 suppl.1 2016
Direitos:  info:eu-repo/semantics/openAccess
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