| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Pseudorabies virus can be classified into five genotypes using partial sequences of UL44
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| Autores: |
Fonseca Jr.,A. A.
Camargos,M. F.
Sales,M. L.
Heinemann,M. B.
Leite,R.C.
Reis,J. K. P.
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| Data: |
2012-12-01
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| Ano: |
2012
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| Palavras-chave: |
Pseudorabies
Glycoprotein
Bioinformatics
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| Resumo: |
Suid herpesvirus 1 (SuHV-1) is the causative agent of pseudorabies (PR), a disease of great importance due to the huge losses it causes in the swine industry. The aim of this study was to determine a method for genotyping SuHV-1 based on partial sequences of the gene coding for glycoprotein C (gC) and to elucidate the possible reasons for the variability of this region. A total of 109 gCsequences collected from GenBank were divided into five major groups after reconstruction of a phylogenetic tree by Bayesian inference. The analysis showed that a portion of gC (approximately 671 bp) is under selective pressure at various points that coincide with regions of protein disorder. It was also possible to divide SuHV-1 into five genotypes that evolved under different selective pressures. These genotypes are not specific to countries or continents, perhaps due to multiple introduction events related to the importation of swine.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400048
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-83822012000400048
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.43 n.4 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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