| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Brazilian propolis protects Saccharomyces cerevisiae cells against oxidative stress
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| Autores: |
Sá,Rafael A. de
Castro,Frederico A.V. de
Eleutherio,Elis C.A.
Souza,Raquel M. de
Silva,Joaquim F.M. da
Pereira,Marcos D.
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| Data: |
2013-09-01
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| Ano: |
2013
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| Palavras-chave: |
Propolis
Antioxidant
Oxidative stress
Saccharomyces cerevisiae
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| Resumo: |
Propolis is a natural product widely used for humans. Due to its complex composition, a number of applications (antimicrobial, antiinflammatory, anesthetic, cytostatic and antioxidant) have been attributed to this substance. Using Saccharomyces cerevisiae as a eukaryotic model we investigated the mechanisms underlying the antioxidant effect of propolis from Guarapari against oxidative stress. Submitting a wild type (BY4741) and antioxidant deficient strains (ctt1∆, sod1∆, gsh1∆, gtt1∆ and gtt2∆) either to 15 mM menadione or to 2 mM hydrogen peroxide during 60 min, we observed that all strains, except the mutant sod1∆, acquired tolerance when previously treated with 25 µg/mL of alcoholic propolis extract. Such a treatment reduced the levels of ROS generation and of lipid peroxidation, after oxidative stress. The increase in Cu/Zn-Sod activity by propolis suggests that the protection might be acting synergistically with Cu/Zn-Sod.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300051
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-83822013005000062
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.44 n.3 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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