| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
The prevalence of aminoglycoside-modifying enzyme and virulence genes among enterococci with high-level aminoglycoside resistance in Inner Mongolia, China
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| Autores: |
Niu,Haiying
Yu,Hui
Hu,Tangping
Tian,Gailin
Zhang,Lixia
Guo,Xiang
Hu,Hai
Wang,Zhanli
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| Data: |
2016-09-01
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| Ano: |
2016
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| Palavras-chave: |
Enterococcus
High-level aminoglycoside resistance
Aminoglycoside-modifying enzyme gene
Virulence determinant
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| Resumo: |
ABSTRACT This study highlights the prevalence of aminoglycoside-modifying enzyme genes and virulence determinants among clinical enterococci with high-level aminoglycoside resistance in Inner Mongolia, China. Screening for high-level aminoglycoside resistance against 117 enterococcal clinical isolates was performed using the agar-screening method. Out of the 117 enterococcal isolates, 46 were selected for further detection and determination of the distribution of aminoglycoside-modifying enzyme-encoding genes and virulence determinants using polymerase chain reaction -based methods. Enterococcus faecium and Enterococcus faecalis were identified as the species of greatest clinical importance. The aac(6')-Ie-aph(2")-Ia and ant(6')-Ia genes were found to be the most common aminoglycoside-modifying enzyme genes among high-level gentamicin resistance and high-level streptomycin resistance isolates, respectively. Moreover, gelE was the most common virulence gene among high-level aminoglycoside resistance isolates. Compared to Enterococcus faecium, Enterococcus faecalis harbored multiple virulence determinants. The results further indicated no correlation between aminoglycoside-modifying enzyme gene profiles and the distribution of virulence genes among the enterococcal isolates with high-level gentamicin resistance or high-level streptomycin resistance evaluated in our study.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000300691
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1016/j.bjm.2016.04.003
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.47 n.3 2016
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| Direitos: |
info:eu-repo/semantics/openAccess
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