| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution
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| Autores: |
Sousa,Sandra Alves de
Pascoa,Henrique
Conceição,Edemilson Cardoso da
Alves,Suzana Ferreira
Diniz,Danielle Guimarães Almeida
Paula,José Realino de
Bara,Maria Teresa Freitas
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| Data: |
2011-06-01
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| Ano: |
2011
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| Palavras-chave: |
Herbal medicines/quality control
Herbal medicines/dissolution behavior
Medicinal plants
Guaraná/pharmacognosy
Paullinia cupana/pharmacognosy
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| Resumo: |
"Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of the dissolved markers. In other capsules, marker dissolution did not exceed 60% whereas 60% of the samples had some characteristic pharmacotechnical problems. These results evidence the need for rigorous quality control to help ensure the therapeutic action of these drugs. To this end, dissolution studies are an essential tool for quality assurance of herbal medicines.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200008
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000200008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.2 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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