| Registro completo |
| Provedor de dados: |
60
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| País: |
Brazil
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| Título: |
Determination of carbamazepine in pharmaceutical formulations
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| Autores: |
Solon,Lílian Grace da Silva
Oliveira,Ana Isabel Maia de
Guerra,Gerlane Coelho Bernardo
Soares,Luiz Alberto Lira
Araújo,Aurigena Antunes de
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| Data: |
2010-09-01
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| Ano: |
2010
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| Palavras-chave: |
Carbamazepine
Medicines/quality control
Generic medicines
Similar medicines
Medicines/magistral formulation
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| Resumo: |
The aim of this study was to evaluate the quality of five different solid formulations of carbamazepine. The reference formulation was Tegretol® 200.00 mg (Novartis) and the others were: generic formulation of carbamazepine 200.00 mg (National Industry), similar formulation of carbamazepine 200.00 mg (National Industry), and two formulations of carbamazepine 200.00 mg acquired from two different compounding pharmacies. The latter consisted of capsules obtained in Natal, the capital city of the Brazilian State of Rio Grande do Norte. The quality of samples was evaluated through physical and physical-chemical tests, including: weight, diameter, thickness, content, dissolution, disintegration, hardness, friability and moisture. The results of friability analysis showed that all formulations met Brazilian and United States Pharmacopeia (USP) specifications. In spite of having a higher hardness compared to the reference, the generic formulation had a lower disintegration time. This could be associated to the presence of crospovidone in its formulation. Results of this study showed that all formulations had dissolutions which were in accordance with Brazilian Pharmacopoeia specifications, and quality control tests. An exception was found for the similar formulation, which had a hardness parameter that exceeded the USP standard. However, this difference was not significant given the similar formulation's satisfactory disintegration time.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300014
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000300014
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.3 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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