| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
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| Autores: |
Rocha,Letícia Fernandes da
Pippi,Bruna
Fuentefria,Alexandre Meneghello
Mezzari,Adelina
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
Cryptococcus neoformans
Ibuprofen
Itraconazole
Fluconazole
Synergism
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| Resumo: |
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100577
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/s2175-97902019000318599
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.56 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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