| Registro completo |
| Provedor de dados: |
BJPS
|
| País: |
Brazil
|
| Título: |
Pharmacokinetics of oleracimine in rats by ultra-high-performance liquid chromatography
|
| Autores: |
Qu,Gonglin
Xu,Liang
Zhang,Wenjie
Ying,Xixiang
|
| Data: |
2018-01-01
|
| Ano: |
2018
|
| Palavras-chave: |
Portulaca oleracea L./Oleracimine
Ultra-High-Performance Liquid Chromatography/Rat plasma
Pharmacokinetics
|
| Resumo: |
The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400611
|
| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
|
| Relação: |
10.1590/s2175-97902018000417242
|
| Formato: |
text/html
|
| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.54 n.4 2018
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
