| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)
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| Autores: |
Kalegari,Milena
Miguel,Marilis Dallarmi
Dias,Josiane de Fátima Gaspari
Lordello,Ana Luísa Lacava
Lima,Cristina Peitz de
Miyazaki,Cristina Mayumi Sasaki
Zanin,Sandra Maria Warumby
Verdam,Maria Christina dos Santos
Miguel,Obdulio Gomes
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| Data: |
2011-09-01
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| Ano: |
2011
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| Palavras-chave: |
Rourea induta/phytochemistry
Connaraceae/phytochemistry
Flavonoids
N-tetracosane
Plant extracts/toxicity
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| Resumo: |
Most active plants are toxic at high doses and it is therefore important to investigate the preliminary toxicity of plant extracts. The Rourea induta species is a potential drug with no phytochemical or biological studies registered in the literature. Thus, a phytochemical study and a toxicity analysis of the ethanolic extract obtained from the leaves of Rourea induta Planch., Connaraceae, was run. A long chain hydrocarbon, n-tetracosane, and four flavonoids were identified: quercetin, and three glycosylated derivates, quercetin-3-O-α-arabinofuranoside, quercetin-3-O-β-xyloside and quercetin-3-O-β-galactoside. This is the first time these have been isolated in this species. The structures were elucidated by 13C NMR, ¹H NMR, UV and IR spectroscopy. The toxicity evaluation of extracts was performed by the brine shrimp method and determination of hemolytic activity. The samples demonstrated no toxic potential by the analyzed methods.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300023
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502011000300023
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.47 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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