Registro completo |
Provedor de dados: |
BJPS
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País: |
Brazil
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Título: |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
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Autores: |
Taghe,Shiva
Mirzaeei,Shahla
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Data: |
2019-01-01
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Ano: |
2019
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Palavras-chave: |
Ocular drug delivery
Nanoparticles
Corneal penetration
Ofloxacin
Chitosan
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Resumo: |
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100519
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Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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Relação: |
10.1590/s2175-97902019000117105
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Formato: |
text/html
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Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.55 2019
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Direitos: |
info:eu-repo/semantics/openAccess
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