| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Anticonvulsant activity of Bacopa monniera in rodents
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| Autores: |
Kaushik,Darpan
Tripathi,Ashish
Tripathi,Rashmi
Ganachari,Madiwalayya
Khan,Suroor Ahmad
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| Data: |
2009-12-01
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| Ano: |
2009
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| Palavras-chave: |
Bacopa monniera/pharmacognosy
Anticonvulsant
MES test
PTZ model
Hypoxia model
Strychnine model
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| Resumo: |
Bacopa monnieri (L), belonging to the Scrophulariaceae family and commonly known as Brahmi, is well known in India for its CNS activity but its neuropharmacological effect has not yet been explored. In the present study, the antiepileptic effects of the plant were investigated. The ethanolic extract of Bacopa monniera was tested for anticonvulsant activity in albino rats, using different convulsive models. The ethanolic extract of leaves produced significant anticonvulsant activity for all the different models studied. The present study shows a probable mechanism of action similar to that of benzodiazepines (GABA agonist). Thus, these results emphasize the need to diversify by using alternative therapeutic approaches pertaining to herbal medicine, where a single easily available plant may provide solutions to several therapeutic challenges, as observed in the anticonvulsant action of ethanolic extract of B. monniera.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400006
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502009000400006
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.45 n.4 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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