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Provedor de dados:  BJPS
País:  Brazil
Título:  Effect of prodigiosin on the alleviation of the intestinal inflammation of weaned rats based on 1H-NMR spectroscopy study and biochemistry indexes
Autores:  Yang,Peizhou
Wu,Yun
Qian,Jing
Cai,Kezhou
Cao,Lili
Zheng,Zhi
Luo,Shuizhong
Jiang,Shaotong
Zhu,Xingxing
Data:  2019-01-01
Ano:  2019
Palavras-chave:  Prodigiosin/pharmacokinetics
Proton Magnetic Resonance Spectroscopy/method
Intestinal Absorption/drug effects
Metabolomics/ methods
Rats/weaned
Metabolism/drug effects
Resumo:  Weaning results in intestinal dysfunction, mucosal atrophy, transient anorexia, and intestinal barrier defects. In this study, the effect of prodigiosin (PG) on the intestinal inflammation of weaned rats was investigated by using 1H-NMR spectroscopy and biochemistry indexes to regulate the intestinal metabolism. After administration for 14 days, the body mass of the PG group was increased by 1.29- and 1.26-fold compared with those of the control and alcohol groups, respectively, using a dose of 200 µg PG·kg-1 body weight per day. PG increased organic acid content and decreased moisture, pH values, and free ammonia in feces. In addition, PG alleviated the intestinal inflammation of weaned rats. The analysis of 1H-NMR signal peak attribution and the model validation of metabolic data of feces contents showed that PG significantly affected the metabolism of small molecular compounds in the intestinal tract of weaned rats. This study presents the promising alternative of using PG to alleviate intestinal inflammation effectively in the intestinal tract of weaned rats.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100589
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/s2175-97902019000217819
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.55 2019
Direitos:  info:eu-repo/semantics/openAccess
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