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Provedor de dados:  BJPS
País:  Brazil
Título:  Stability-indicating RP-HPLC method for determination of beclomethasone dipropionate in nanocapsule suspensions
Autores:  Chassot,Janaíne Micheli
Ferreira,Luana Mota
Gomes,Felipe Pereira
Cruz,Letícia
Tasso,Leandro
Data:  2015-12-01
Ano:  2015
Palavras-chave:  High performance liquid chromatography/reverse phase/quantitative analysis
Beclomethasone dipropionate/determination
Nanocapsule/suspensions
Nanoparticles.
Resumo:  abstract A simple stability-indicating RP-HPLC/UV method was validated for determination of beclomethasone dipropionate (BD) in nanocapsule suspensions. Chromatographic conditions consisted of a RP C18column (250 mm x 4.60 mm, 5 µm, 110 Å), using methanol and water (85:15 v/v) as mobile phase at 1.0 mL/min with UV detection at 254 nm. The calibration curve was found to be linear in the concentration range of 5.0-25.0 µg/mL with a correlation coefficient > 0.999. Precision was demonstrated by a relative standard deviation lower than 2.0%. Accuracy was assessed by the recovery test of BD from nanocapsules (98.03% to 100.35%). Specificity showed no interference from the components of nanocapsules or from the degradation products derived from acid, basic and photolytic conditions. In conclusion, the method is suitable to be applied to assay BD in bulk drug and in nanocapsules, and it can be employed to study stability and degradation kinetics.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400803
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502015000400006
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.51 n.4 2015
Direitos:  info:eu-repo/semantics/openAccess
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