| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
WBC count and functional changes induced by co-administration of clofazimine and clarithromycin, in single and multiple doses, in Wistar rats
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| Autores: |
Paina,Flávia Aparecida
Miranda,Julise Cunha
Tavares,Cristiane Fernandes de Freitas
Queiroz,Regina Helena da Costa
Souza,Ana Maria de
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| Data: |
2012-09-01
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| Ano: |
2012
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| Palavras-chave: |
Clofazimine/adverse effects
Clofazimine/experimental study
Clarithromycin/adverse effects
Clarithromycin/experimental study
Leprosy/treatment
Mycobacterium avium/infections
Mycobacterium avium/treatment
Leukocytes
Phagocytosis
Oxidative burst
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| Resumo: |
Clofazimine and clarithromycin are used to treat leprosy and infections caused by Mycobacterium avium complex. Little data on the toxicity of co-administration of these two drugs are available. Here we evaluated the potential adverse effects of polytherapy with these two drugs in male Wistar rats by determining WBCs counts and other blood cell counts, neutrophilic phagocytosis, and burst oxidative, by flow cytometry. We observed an increase in WBCs, in multiple-dose regimens, and in polymorphonuclear cells, in both single- clarithromycin only and multiple dose regimens. We also observed a reduction in mononuclear cell counts in single and multiple doses. The drugs seem to reverse the mononuclear and polymorphonuclear cell ratio. An increase in oxidative burst was observed in animals treated with the drugs administered either individually or combined. In conclusion, clofazimine and clarithromycin change WBCs counts. Our results may contribute for a better understanding of the mechanisms related to the effects of co-administrating the two drugs.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300008
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502012000300008
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.48 n.3 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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