| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations
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| Autores: |
Leandro,Katia Christina
Carvalho,Juliana Machado de
Giovanelli,Luiz Fernando
Moreira,Josino Costa
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| Data: |
2009-06-01
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| Ano: |
2009
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| Palavras-chave: |
Isoniazid
Rifampicin
Tuberculosis/treatment
Tuberculostatics/quantitative analysis
Differential pulse voltammetry
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| Resumo: |
Tuberculosis remains a major public health problem, especially in developing countries. Brazil presents the largest number of cases in Latin America and is among the 22 countries considered priorities by the World Health Organization (WHO). The Rio de Janeiro state has the largest number of cases registered in the country. The treatment of patients, commonly, makes use of the drugs isoniazid and rifampicin for six months. This study aimed to develop and validate an electroanalytical methodology, using the technique of differential pulse voltammetry for the determination of these drugs in the associated form, in order to evaluate the quality of medicines distributed in the state of Rio de Janeiro. The potential reduction for the isoniazid and rifampicin were -1.10 and -0.90 V. The developed and validated electroanalytical method presented a linear range of 0.25 to 1.25 mg/L to isoniazid, limits of detection and quantification of 0.05 and 0.14 mg/L, and recovery of 98.2 ± 0.4%; a tracking linear of 0.40 to 2.00 mg/L for rifampicin, with limits of detection and quantification of 0.07 and 0.19 mg/L and recovery of 95.8 ± 0.6%. Six lots of medicines from two pharmaceutical companies were analyzed. Only one of the samples showed unsatisfactory levels of rifampicin.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000200019
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502009000200019
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.45 n.2 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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