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Provedor de dados:  BJPS
País:  Brazil
Título:  Formulation of gastroretentive floating drug delivery system using hydrophilic polymers and its in vitro characterization
Autores:  Meka,Venkata Srikanth
Dharmanlingam,Senthil Rajan
Kolapalli,Venkata Ramana Murthy
Data:  2014-06-01
Ano:  2014
Palavras-chave:  Gastroretentive floating/ drug delivery system
Gastroretentive floating tablets/in vitro dissolution
Hydrophilic polymers/use in drug delivery system
Polyethylene oxide
Propranolol HCl/delivery system
Resumo:  The aim of the present research is to formulate and evaluate the gastroretentive floating drug delivery system of antihypertensive drug, propranolol HCl. Gastroretentive floating tablets (GRFT) were prepared by using a synthetic hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K and PEO 18 NF as release retarding polymers and calcium carbonate as gas generating agent. The GRFT were compressed by direct compression strategy and the tablets were evaluated for physico-chemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 9 was selected as an optimized formulation. The optimized formulation followed zero order rate kinetics with non-Fickian diffusion mechanism. The optimized formulation was characterised with FTIR studies and observed no interaction between the drug and the polymers.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200431
Editor:  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação:  10.1590/S1984-82502014000200023
Formato:  text/html
Fonte:  Brazilian Journal of Pharmaceutical Sciences v.50 n.2 2014
Direitos:  info:eu-repo/semantics/openAccess
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