| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Antitumor activity of leaves of Himatanthus drasticus (Mart.) Plumel-Apocynaceae (janaguba) in the treatment of Sarcoma 180 tumor
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| Autores: |
Sousa,Eliane Leite de
Grangeiro,Ana Ruth Sampaio
Bastos,Isla Vanessa Gomes Alves
Rodrigues,Guilherme Carvalho Ribeiro
Silva,Maria Joselice e
Anjos,Falba Bernadete Ramos dos
Souza,Ivone Antonia de
Sousa,Cicero Ernandes Leite de
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Himatanthus drasticus/antitumor activity
Himatanthus drasticus/acute oral toxicity
Janaguba/antitumor activity
Sarcoma 180/experimental study
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| Resumo: |
Himatanthus drasticus, also known as janaguba, is used popularly in Brazil's Northeastern region in the treatment of cancer. However, no scientific reports are available. The present study is the first investigation on the antitumor activity of crude methanolic extract from Himatanthus drasticus leaves against Sarcoma 180 tumor and on its side effects including acute oral toxicity. The OECD 423 methodology was used to study acute oral toxicity, and the STOCK methodology to assess antitumor activity. The crude extract showed low toxicity at the tested doses (50, 300 and 2000 mg/kg) administered orally. The histopathological analyses demonstrated alterations in liver lung, spleen and kidney. It also showed activity against Sarcoma 180 tumor in male Swiss albino mice, evidencing tumor growth inhibition of 67.7% and 68% at 300 mg/kg and 400 mg/kg doses, respectively.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200005
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000200005
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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