| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Thermodynamic study of the solubility of ibuprofen in acetone and dichloromethane
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| Autores: |
Aragón,Diana Marcela
Rosas,Jaiver Eduardo
Martínez,Fleming
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Ibuprofen
Solubility
Transfer
Solution thermodynamics
Organic solvents
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| Resumo: |
Thermodynamic functions, Gibbs energy, enthalpy and entropy for the solution processes of ibuprofen (IBP) in acetone and dichloromethane (DCM) were calculated from solubility values obtained at temperatures ranging from 293.15 K to 313.15 K. The respective thermodynamic functions for mixing and solvation processes as well as the activity coefficients for the solute were calculated. IBP solubility was high and proved similar in both solvents but was greater in DCM than acetone. In addition, the thermodynamic quantities for the transfer process of this drug from cyclohexane to the organic solvents were also calculated in order to estimate the contributions of hydrogen-bonds or of other dipolar interactions. The results were discussed in terms of solute-solvent interactions.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200009
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502010000200009
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.46 n.2 2010
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| Direitos: |
info:eu-repo/semantics/openAccess
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