| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Study of the correlation between blood cholinesterases activity, urinary dialkyl phosphates, and the frequency of micronucleated polychromatic erythrocytes in rats exposed to disulfoton
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| Autores: |
Santos,Mariane Gonçalves
Vitor,Ricardo Vilela
Nakamura,Maurício Gustavo
Morelini,Luana de Souza
Ferreira,Rafaela Scalco
Paiva,Alexandre Giusti
Azevedo,Luciana
Marques,Vanessa Bergamin Boralli
Martins,Isarita
Figueiredo,Eduardo Costa
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| Data: |
2013-03-01
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| Ano: |
2013
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| Palavras-chave: |
Pesticides/exposure study
Organophosphate/exposure study
Disulfoton/exposure
Dialkyl phosphate/urinary excretion
Blood cholinesterase
Micronucleated polychromatic erythrocytes/frequency
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| Resumo: |
Organophosphates (OPs) are widely used as pesticides, and its urinary metabolites as well as the blood cholinesterases (ChEs) activity have been reported as possible biomarkers for the assessment of this pesticide exposure. Moreover, the OPs can induce mutagenesis, and the bone marrow micronucleus test is an efficient way to assess this chromosomal damage. This paper reports a study carried out to verify the correlation among the disulfoton exposure, blood ChEs activity, urinary diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), as well as micronucleated polychromatic erythrocytes (MNPCEs) frequency. Four groups of rats (n=12) were exposed to disulfoton at 0, 2.8, 4.7, and 6.6 mg kg-1 body weight. The blood ChEs activity, urinary DETP and DEDTP concentrations, and MNPCEs frequency were determined. It was observed that the plasmatic and erythrocytary ChEs activity decreased from 2.9% to 0.5% and from 35.9 to 3.3%, respectively, when the disulfoton dose was increased from 0 to 6.6 mg kg-1 (correlation of 0.99). Urinary DETP and DEDTP concentrations, as well as the MNPCEs frequency, increased from 0 to 6.58 µg mL-1, from 0 to 0.04 µg mL-1, and from 0 to 1.4%, respectively, when the disulfoton dose was increased from 0 to 6.58 mg kg-1 body weight.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100016
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502013000100016
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.49 n.1 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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