| Registro completo |
| Provedor de dados: |
Ciência Rural
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| País: |
Brazil
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| Título: |
Different leaf extracts from Brunfelsia uniflora in mice
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| Autores: |
Carvalho,Ciro José Sousa de
Melo,Marília Martins
Michell,Ana Flávia Ribeiro Machado
Torres,Bruno Benetti Junta
Riet-Correa,Franklin
Guedes,Roberto Maurício Carvalho
Ferraz,Vany Perpetua
Soto-Blanco,Benito
Silva,Silvana Maria Medeiros de Sousa
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| Data: |
2018-01-01
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| Ano: |
2018
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| Palavras-chave: |
Toxicity
Alkaloids
Saponins
Flavonoids
Brunfelsia
Solanaceae
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| Resumo: |
ABSTRACT: In Brazil, at least 16 poisonous plant species can affect the central nervous system of livestock. Recently in the state of Piauí, Northeastern Brazil, Brunfelsia uniflora was reported as a cause of nervous signs in donkeys, cattle, and small ruminants. In order to assess the toxicity of B. uniflora extracts, 20 Swiss mice were distributed into four groups (n=5) receiving by gavage alkaloids, flavonoids, saponins, or saline (control group). After administration of the extracts in a single dose (5g kg-1), all mice were observed daily for clinical signs. Mice that received the extracts showed moderate to severe clinical signs, including piloerection, vocalization, and seizures. All mice dosed with saponins died between 10 and 20min after administration. Serum biochemical evaluation of animals that received saponins revealed slight increases in total protein levels and decreased magnesium and chlorite levels. In conclusion, saponins of B. uniflora leaves induced acute toxic neurological effects and death in mice.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100552
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| Editor: |
Universidade Federal de Santa Maria
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| Relação: |
10.1590/0103-8478cr20170246
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| Formato: |
text/html
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| Fonte: |
Ciência Rural v.48 n.1 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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