| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Combined genotypes of the MBL2 gene related to low mannose-binding lectin levels are associated with vaso-occlusive events in children with sickle cell anemia
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| Autores: |
Medeiros,Fernanda Silva
Mendonça,Taciana Furtado de
Lopes,Katiuscia Araújo de Miranda
França,Laís Medeiros da Câmara
Silva,Andreia Soares da
Vasconcelos,Luydson Richardson Silva
Oliveira,Maria do Carmo Valgueiro Costa de
Anjos,Ana Cláudia Mendonça dos
Hatzlhofer,Betânia Lucena Domingues
Bezerra,Marcos André Cavalcanti
Araújo,Aderson da Silva
Moura,Patrícia
Cavalcanti,Maria do Socorro de Mendonça
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| Data: |
2017-09-01
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| Ano: |
2017
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| Palavras-chave: |
MBL2
Polymorphism
Sickle cell anemia
Vaso-occlusive events
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| Resumo: |
Abstract Sickle cell anemia (SCA) presents heterogenous clinical manifestations that cannot be explained solely by alterations to hemoglobin (Hb); other components such as endothelial adhesion, thrombosis and inflammation may be involved. The mannose-binding lectin (MBL) has an important role in innate immunity and inflammatory diseases. In this report, we describe an association between MBL2 polymorphism related to low production of serum MBL and the frequency of vasoocclusive events (FVOE) in children ≤ 5 years old with SCA (p = 0.0229; OR 5.55; CI 1.11-27.66). Further studies are needed to explore the role of low MBL2 in the pathophysiology of vasoocclusive events in SCA.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000400600
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2016-0161
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.40 n.3 2017
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| Direitos: |
info:eu-repo/semantics/openAccess
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