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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  Non-random distribution of high density chromatin detected at opposite ends of T-banded human metaphase chromosomes
Autores:  Santiñaque,Federico F.
Drets,Máximo E.
Data:  2007-01-01
Ano:  2007
Palavras-chave:  Human chromosomes
T-banding
Chromatin structure
Telomere
Microdensitometry
Resumo:  Previous research using microdensitometric scanning and computer graphic image analysis showed that T-banded segments of human metaphase chromosomes usually exhibit an asymmetrical distribution of high density (HD) chromatin between sister chromatids. Here, we employed the same methods to analyze HD chromatin distribution at opposite ends of T-banded human lymphocyte chromosomes. This study revealed that in most chromosomes with an asymmetrical distribution of HD chromatin at both ends, the highest densities of each arm were located in opposite chromatids. The frequency of this configuration was 0.792 per chromosome, indicating that the highest chromatin densities of the terminal segments of T-banded human chromosomes were non-randomly distributed at opposite chromosome arms. The possible relationship of this observation to the mode of replication of the terminal chromosome region is briefly discussed.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000600004
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572007000600004
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.30 n.4 2007
Direitos:  info:eu-repo/semantics/openAccess
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