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Provedor de dados:  Genet. Mol. Biol.
País:  Brazil
Título:  CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population
Autores:  Coura,Renata dos Santos
Marques,Christiane de Fátima Silva
Koifman,Rosalina J.
Koifman,Sergio
Cabello,Pedro Hernan
Hatagima,Ana
Data:  2007-01-01
Ano:  2007
Palavras-chave:  Cytochromes P450
CYP1A1
CYP2E1
Brazil
Resumo:  The enzymes encoded by the polymorphic genes CYP1A1 and CYP2E1 play an important role in the activation and inactivation of xenobiotics. These enzymes have been associated with xenobiotic-induced diseases, such as cancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro. Polymorphisms CYP1A1 and CYP2E1 were determined in 870 unrelated individuals by PCR-RFLP analysis in peripheral blood DNA. The observed allelic frequencies were 0.90 for CYP1A1*1A and 0.95 for CYP2E1*1A, in the total sample. The allelic frequency of CYP1A1*2C in "pardos" (0.13) and Brazilian whites (0.11) was higher than in Caucasians (0.05), which may be a result of the Amerindian genetic component, that presents the highest frequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups.
Tipo:  Info:eu-repo/semantics/article
Idioma:  Inglês
Identificador:  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100001
Editor:  Sociedade Brasileira de Genética
Relação:  10.1590/S1415-47572007000100001
Formato:  text/html
Fonte:  Genetics and Molecular Biology v.30 n.1 2007
Direitos:  info:eu-repo/semantics/openAccess
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