| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide
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| Autores: |
Schneider,Beatriz Ursinos Catelan
Meza,Alisson
Beatriz,Adilson
Pesarini,João Renato
Carvalho,Pamela Castilho de
Mauro,Mariana de Oliveira
Karaziack,Caroline Bilhar
Cunha-Laura,Andréa Luiza
Monreal,Antônio Carlos Duenhas
Matuo,Renata
Lima,Dênis Pires de
Oliveira,Rodrigo Juliano
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| Data: |
2016-06-01
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| Ano: |
2016
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| Palavras-chave: |
Phenolic lipid
Antimutagenesis
Micronucleus
Comet assay
Apoptosis
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| Resumo: |
Abstract Cardanol is an effective antioxidant and is a compound with antimutagenic and antitumoral activity. Here, we evaluated the genotoxic and mutagenic potential of saturated side chain cardanol and its effects in combination with cyclophosphamide in preventing DNA damage, apoptosis, and immunomodulation. Swiss mice were treated with cardanol (2.5, 5 and 10 mg/kg) alone or in combination with cyclophosphamide (100 mg/kg). The results showed that cardanol is an effective chemopreventive compound, with damage reduction percentages that ranged from 18.9 to 31.76% in the comet assay and from 45 to 97% in the micronucleus assay. Moreover, cardanol has the ability to reduce the frequency of apoptosis induced by cyclophosphamide. The compound did not show immunomodulatory activity. A final interpretation of the data showed that, despite its chemoprotective capacity, cardanol has a tendency to induce DNA damage. Hence, caution is needed if this compound is used as a chemopreventive agent. Also, this compound is likely not suitable as an adjuvant in chemotherapy treatments that use cyclophosphamide.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200279
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/1678-4685-gmb-2015-0170
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.39 n.2 2016
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| Direitos: |
info:eu-repo/semantics/openAccess
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