| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans
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| Autores: |
Peralta-Leal,Valeria
Leal-Ugarte,Evelia
Meza-Espinoza,Juan P.
Dávalos-Rodríguez,Ingrid P.
Bocanegra-Alonso,Anabel
Acosta-González,Rosa I.
Gonzales,Enrique
Nair,Saraswathy
Durán-González,Jorge
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| Data: |
2012-01-01
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| Ano: |
2012
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| Palavras-chave: |
SLC6A4 gene
5-HTTLPR polymorphism
Type 2 diabetes mellitus
Body mass index
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| Resumo: |
The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy- Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400007
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572012005000048
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.35 n.3 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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