| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
The prion protein and New World primate phylogeny
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| Autores: |
Schneider,Igor
Schneider,Horacio
Schneider,Maria Paula
Silva,Artur
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| Data: |
2004-01-01
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| Ano: |
2004
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| Palavras-chave: |
Prion protein
New World monkeys
Molecular phylogeny
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| Resumo: |
The PrP C prion protein contains 250 amino acids with some variation among species and is expressed in several cell types. PrP C is converted to PrP Sc by a post-translational process in which it acquires amino acid sequences of three-dimensional conformation of beta-sheets. Variations in the prion protein gene were observed among 16 genera of New World primates (Platyrrhini), and resulted in amino acid substitutions when compared with the human sequence. Seven substitutions not yet described in the literature were found: W -> R at position 31 in Cebuella, T -> A at position 95 in Cacajao and Chiropotes, N-> S at position 100 in Brachyteles, L -> Q at position 130 in Leontopithecus (in the sequence responsible for generating the beta-sheet 1), D -> E at position 144 in Lagothrix (in the sequence responsible for the alpha-helix 1), D-> G at position 147 in Saguinus (also located in the alpha-helix 1 region), and M -> I at position 232 in Alouatta. The phylogenetic trees generated by parsimony, neighbor-joining and Bayesian analyses strongly support the monophyletic status of the platyrrhines, but did not resolve relationships among families. However, the results do corroborate previous findings, which indicate that the three platyrrhine families radiated rapidly from an ancient split.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400007
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572004000400007
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.27 n.4 2004
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| Direitos: |
info:eu-repo/semantics/openAccess
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