Registro completo |
Provedor de dados: |
Genet. Mol. Biol.
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País: |
Brazil
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Título: |
Butyrylcholinesterase genetic variability in Guarani Amerindians from the Brazilian state of Mato Grosso do Sul
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Autores: |
Furtado,Lupe
Souza,Ricardo L. R.
Tsuneto,Luiza T.
Petzl-Erler,Maria Luiza
Chautard-Freire-Maia,Eleidi A.
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Data: |
2006-01-01
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Ano: |
2006
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Palavras-chave: |
BCHE gene
A allele
F-2 and K alleles
Guarani-Kaiowá
Guarani-Ñandeva
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Resumo: |
Human butyrylcholinesterase (BChE; EC 3.1.1.8) is a polymorphic enzyme coded by the BCHE gene (3q26.1-q26.2) while the CHE2 gene (2q33-q35) determines a still not characterized substance that forms a complex with BChE (C5), being the CHE2 C5+ and CHE2 C5- phenotypes detected in electrophoresis. The present study investigated BCHE and CHE2 variability and the BChE activity of Brazilian Guarani Amerindians from the Kaiowá and Ñandeva sub-groups living in several indigenous territories in the Brazilian state of Mato Grosso do Sul. The frequency of the BCHE exon 2 D70G (A) allele was 0.60% ± 0.35% while that of the BCHE exon 2 G390V (F-2) allele, never before screened in Amerindians, was 8.82% ± 1.35%. This is the first time that the BCHE gene exon 4 A539T (K) allele has been surveyed in Brazilian Amerindians where it was found at a frequency of 3.69% ± 0.85%, similar to that found in Chilean Mapuche Amerindians. The BCHE gene variability seen in this survey differs from that of non-isolated populations in respect to both A539T and G390V allele frequency. The CHE2 C5+ phenotype frequency was 14.40% ± 2.22% and falls within the range of that found for other Brazilian Amerindian samples.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100002
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Editor: |
Sociedade Brasileira de Genética
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Relação: |
10.1590/S1415-47572006000100002
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Formato: |
text/html
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Fonte: |
Genetics and Molecular Biology v.29 n.1 2006
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Direitos: |
info:eu-repo/semantics/openAccess
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