| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Evaluation of extracts from Coccoloba mollis using the Salmonella/microsome system and in vivo tests
|
| Autores: |
Tsuboy,Marcela Stefanini
Marcarini,Juliana Cristina
Ferreira,Dalva Trevisan
Ferraz,Elisa Raquel Anastácio
Chequer,Farah Maria Drumond
Oliveira,Danielle Palma de
Ribeiro,Lúcia Regina
Mantovani,Mário Sérgio
|
| Data: |
2010-01-01
|
| Ano: |
2010
|
| Palavras-chave: |
Medicinal plants
Coccoloba mollis
Ames test
In vivo comet assay
In vivo micronucleus assay
Polygonaceae
|
| Resumo: |
The common everyday use of medicinal plants is an ancient, and still very widespread practice, whereby the need for studies on their possible toxicity and mutagenic properties. The species Coccoloba mollis has been much used in phytotherapy, mainly in cases involving loss of memory and stress. In order to investigate its genotoxic and mutagenic potential, ethanolic extracts from the leaves and roots underwent Salmonella/microsome assaying (TA98 and TA100 strains, with and without exogenous metabolism - S9), besides comet and micronucleus tests in vivo.There was no significant increase in the number of revertants/plate of Salmonella strains in any of the analyzed root-extract concentrations, although the extract itself was extremely toxic to the Salmonella TA98 strain in the tests carried out with S9 (doses varying from 0.005 to 0.5 µg/plate). On the other hand, the leaf-extract induced mutations in the TA98 strain in the absence of S9 in the highest concentration evaluated, although at very low mutagenic potency (0.004 rev/µg). Furthermore, there was no statistically significant increase in the number of comets and micronuclei, in treatments involving Swiss mice. It was obvious that extracts of Coccoloba mollis, under the described experimental conditions, are not mutagenic.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300027
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572010005000062
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.33 n.3 2010
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
|
