| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5
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| Autores: |
Güllü,Gökçe
Peker,Irem
Haholu,Aptullah
Eren,Fatih
Küçükodaci,Zafer
Güleç,Bülent
Baloglu,Hüseyin
Erzik,Can
Özer,Ayse
Akkiprik,Mustafa
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| Data: |
2015-03-01
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| Ano: |
2015
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| Palavras-chave: |
Breast cancer
ER alpha
IGFBP5
Micro RNA
MiR-140
MiR-193b
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| Resumo: |
The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015). Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009). miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002), whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008). Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049). These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100021
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-475738120140167
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.38 n.1 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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