| Registro completo |
| Provedor de dados: |
International Journal of Morphology
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| País: |
Chile
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| Título: |
Nestin-positive Stem Cells Participate in Chondrocyte Renewal in Healthy Adult Lung Cartilage
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| Autores: |
Ortega-Martínez,Marta
de-la-Garza-González,Carlos
Ancer-Rodríguez,Jesús
Jaramillo-Rangel,Gilberto
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| Data: |
2014-03-01
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| Ano: |
2014
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| Palavras-chave: |
Cartilage
Chondrocyte renewal
Nestin
Stem cells
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| Resumo: |
It is considered that healthy adult cartilage has little or no capacity for renewal, and that chondrocytes maintain a stable resting phenotype and resist proliferation and differentiation throughout life. Recently we found that cell turnover in lung cartilage is possible and that nestin-positive cells may have a role in it. In this paper, we report additional findings about chondrocyte renewal in lung cartilage. Lung specimens from CD1 mice at the age of 2, 6, 12, 18 or 24 months were fixed in 10% neutral-buffered formalin and paraffin-embedded. Nestin expression was examined by an immunohistochemical peroxidase-based method. We found nestin-positive cells inside of cartilage islets and cells in division very close from them. Our findings indicate that there exist nestin-positive mesenchymal stem cells in the adult that are able to differentiate into lung chondrocytes, perhaps to maintain homeostasis or repair damaged tissue. These findings may improve our knowledge about the cartilage biology and could provide new cell candidates for cartilage tissue engineering.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100026
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| Editor: |
Sociedad Chilena de Anatomía
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| Formato: |
text/html
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| Fonte: |
International Journal of Morphology v.32 n.1 2014
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