| Registro completo |
| Provedor de dados: |
International Journal of Morphology
|
| País: |
Chile
|
| Título: |
Ultrastructural Analyses of Platelets and Fibrin Networks in BALB/c Mice after Inhalation of Spherical and Rod-Shaped Titanium Nanoparticles
|
| Autores: |
Oosthuizen,Maria Aletta
Pretorius,Etheresia
Oberholzer,Hester Magdalena
van der Spuy,Wendy Jeannette
|
| Data: |
2010-12-01
|
| Ano: |
2010
|
| Palavras-chave: |
Nanoparticles
TiO2
Platelets
Fibrin
BALB/c murine model
|
| Resumo: |
Engineered nanoparticles are designed to perform specific functions and therefore have specific properties that could potentially be harmful. Nanoparticles such as titanium dioxide have the potential to become transparent and are therefore widely used in cosmetic products and sunscreen. Research on the toxicity of nanoparticles is of utmost importance and numerous in vitro studies have shown that some of these particles could have adverse health effects. The current study aimed to investigate the in vivo effects of two different titanium nanoparticles at two different concentrations after inhalation by experimental BALB/c mice. This was done to determine whether these particles will cause an inflammatory reaction, visible as alterations in platelet and fibrin ultrastructure. Mice were divided into five experimental groups comprising of a control group, high and low concentration groups exposed to the spherical-shaped particles, as well as high and low concentration groups exposed to the rod-shaped particles. The ultrastructure of the fibrin networks and platelet aggregates of these experimental groups were investigated and compared to that of controls. Results indicated that the fibrin networks of the exposed animals have a net-like covering over the major fibres, typical to that found in animals with inflammation. It can therefore be concluded that the nanoparticles used in this study may have the potential to cause an inflammatory reaction, affecting the haemostatic physiology.
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400044
|
| Editor: |
Sociedad Chilena de Anatomía
|
| Formato: |
text/html
|
| Fonte: |
International Journal of Morphology v.28 n.4 2010
|
