| Registro completo |
| Provedor de dados: |
International Journal of Morphology
|
| País: |
Chile
|
| Título: |
Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
|
| Autores: |
Pereira Alves,Angela Maria
de Paula,Anderson Luiz
Moreira,Cassio Rafael
Ferrari,Fernanda
Coelho Leal,Jean Paulo
Hatoum,Ualid Saleh
Vieira Silva,Helaine Maruska
Belato Alves,Eder Paulo
de Miranda Neto,Marcilio Hubner
Galvanini,Paulo Alexandre
|
| Data: |
2017-03-01
|
| Ano: |
2017
|
| Palavras-chave: |
Diabetes mellitus
Enteric neurons
Quercetin
NADH diaphorase
|
| Resumo: |
The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p <0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p <0.01). Animals in D group presented an 18.7 % increase in the cell body areas of myenteric neurons when compared to N (p <0.001); DQ group showed a 14.2 % decrease in neuronal areas when compared to D (p <0.01); the nuclear area were similar among the three groups. We conclude that quercetin supplementation was positive for animals with diabetes mellitus.
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039
|
| Editor: |
Sociedad Chilena de Anatomía
|
| Formato: |
text/html
|
| Fonte: |
International Journal of Morphology v.35 n.1 2017
|
