| Registro completo |
| Provedor de dados: |
J. Venom. Anim. Toxins incl. Trop. Dis.
|
| País: |
Brazil
|
| Título: |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
|
| Autores: |
JKAL,Neves
S,Sarinho
CML,de Melo
VRA,Pereira
MCA,de Lima
IR,Pitta
MCPA,Albuquerque
SL,Galdino
|
| Data: |
2011-01-01
|
| Ano: |
2011
|
| Palavras-chave: |
Schistosoma mansoni
In vitro
Imidazolidines
|
| Resumo: |
Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300007
|
| Editor: |
Centro de Estudos de Venenos e Animais Peçonhentos
|
| Relação: |
10.1590/S1678-91992011000300007
|
| Formato: |
text/html
|
| Fonte: |
Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.3 2011
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
