| Registro completo |
| Provedor de dados: |
Rev. Bras. Ciênc. Avic.
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| País: |
Brazil
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| Título: |
Effects of E. Coli Infection on the Expressions of TGF-β/Smads Signaling Pathway in Broiler Intestine
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| Autores: |
Juang,J
Yin,H
Zhang,C
Wang,J
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
TGF-β/Smads
Intestinal lesion
E. coli
Chicken
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| Resumo: |
ABSTRACT This experiment aimed to investigate whether Escherichia coli (E. coli) infection could affect the TGF-β/smads signaling pathway in the jejunal tissue of chickens. One-day-old Cobb 500 broilers were randomly divided into 2 groups and treated with intraperitoneal E. coli or broth injection. Clinical signs of the birds were assessed every day. Spleen and bursa of Fabricius of the birds, post-infection (pi), were collected to evaluate immune organ index. Jejunal tissues were collected to ascertain the expression of TGF-βs, TβRs, and Smads. The results showed that the infected birds had significantly higher index of the spleen (24hrs and 48hrs pi) compared with birds in the control group (p<0.05). The relative gene expression of TGF-β4 increased (p<0.05), while the expression of Smad7 down-regulated in the E. coli group (p<0.01). There was no significant difference in TGF-β2, TGF-β3, TβR I, TβR II, Smad2, Smad3 expression (p>0.05). In conclusion, TGF-β/Smad signaling pathway was associated with the immune response of broilers in E. coli infection and TGF-β4 was the main subtype interacting with E. coli infection.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2020000100311
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| Editor: |
Fundação APINCO de Ciência e Tecnologia Avícolas
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| Relação: |
10.1590/1806-9061-2019-1101
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Poultry Science v.22 n.1 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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