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OLIVEIRA,MAILCAR F.; LEMOS,TELMA L.G.; MATTOS,MARCOS C. DE; SEGUNDO,TACIANA A.; SANTIAGO,GILVANDETE M.P.; BRAZ-FILHO,RAIMUNDO. |
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lapachol; Enamine derivatives; Biological activities. |
Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004 |
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ARRIAGA,ANGELA M.C.; MESQUITA,ALDENOR C. DE; POULIQUEN,YVONE B.M.; LIMA,ROBERTO A. DE; CAVALCANTE,SERGIO H.; CARVALHO,MARIO G. DE; SIQUEIRA,JOSÉ A. DE; ALEGRIO,LEILA V.; BRAZ-FILHO,RAIMUNDO. |
From the roots, stems and fruits of Simarouba versicolor (Simaroubaceae) were isolated quassinoids (3, 5-7), triterpenoids (8-14), a mixture of steroids (15-17), the flavonoid kaempferol (18) and the squalene derivative 11,14-diacetoxy-7,10; 15,18-diepoxy-6,19-dihidroxy-6,7,10,11,14,15,18,19-octahydrosqualene (19). Spectral data were used for structural characterization. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Simarouba versicolor; Simaroubaceae; Quassinoids; Triterpenoids; Steroids; Flavonoid; Squalene derivative. |
Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300004 |
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RICARTE,LARA P.; BEZERRA,GABRIELI P.; ROMERO,NIRLA R.; SILVA,HORLANDO C. DA; LEMOS,TELMA L.G.; ARRIAGA,ANGELA M. C.; ALVES,PÉRICLES B.; SANTOS,MARCELO B. DOS; MILITÃO,GARDENIA C.G.; SILVA,THIAGO D.S.; BRAZ-FILHO,RAIMUNDO; SANTIAGO,GILVANDETE M.P.. |
Abstract The essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aedes aegypti; Cytotoxic activity; Lamiaceae; Larvicidal activity. |
Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100718 |
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PEREIRA,RAFAEL; PEREIRA,ANNA L.; FERREIRA,MARCILIO M.; FONTENELLE,RAQUEL O.S.; SAKER-SAMPAIO,SILVANA; SANTOS,HÉLCIO S.; BANDEIRA,PAULO N.; VASCONCELOS,MAYRON A.; QUEIROZ,JOSÉ A.N.; BRAZ-FILHO,RAIMUNDO; TEIXEIRA,EDSON H.. |
Abstract: This study evaluated the antibacterial, antifungal, and antioxidant effect of 7-hydroxy-4’,6-dimethoxy-isoflavone and essential oil of Myroxylon peruiferum. The compound was isolated and its structure elucidated by NMR. The chemical composition of essential oil determined by GC-MS analysis. To evaluation of antimicrobial activity, the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were performed. In addition to analysis of antioxidant activity, DPPH radical scavenging tests, iron chelating assay (FIC), antioxidant reducing power assay (FRAP) and β-carotene bleaching assay (BCB) were performed. For the essential oil were identified 24 organized compounds having as main... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Antioxidant activity; Essential oil; Isoflavone; Myroxylon peruiferum. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300602 |
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ALMEIDA,MACIA C.S. DE; SOUZA,LUCIANA G.S.; FERREIRA,DANIELE A.; PINTO,FRANCISCO C.L.; OLIVEIRA,DÉBORA R. DE; SANTIAGO,GILVANDETE M.P.; MONTE,FRANCISCO J.Q.; BRAZ-FILHO,RAIMUNDO; LEMOS,TELMA L.G. DE. |
ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bauhinia pentandra; Fabaceae; Cyanoglucoside; Lactones; RMN.. |
Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100065 |
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