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Vision senses number directly Nature Precedings
John Ross; David C. Burr.
We have recently suggested that numerosity is a primary sensory attribute, showing that it is strongly susceptible to adaptation. Here we use the Method of Single Stimuli (MSS) to show that observers can extract a running average of the numerosity of a succession of stimuli and hold it in mind for use as a standard of comparison for subsequent stimuli. Accuracy and precision of judgments are high and not reduced by potentially misleading variables like texture density or display area.
Tipo: Manuscript Palavras-chave: Neuroscience.
Ano: 2009 URL: http://precedings.nature.com/documents/2792/version/1
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Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2 Nature Precedings
Jianzhi Pan; Koji Nakade; Satoko Masuzaki; Hitomi Hasegawa; Yu-Chang Huang; Takehide Murata; Atsushi Yoshiki; Naoto Yamaguchi; Yuichi Obata; Kazunari K. Yokoyama.
We report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt the site of initiation of transcription. The healing of wounded skin of Jdp2KO mice proceeded more rapidly than that of control mice and more proliferating cells were found at wound margins. Fibroblasts derived from embryos of Jdp2KO mice proliferated more rapidly and formed more colonies than wild-type fibroblasts. JDP2 was recruited to the promoter of the gene for cyclin A2 (ccna2) at a previously unidentified AP-1 site. Cells lacking Jdp2 had elevated levels of cyclin A2 mRNA. Moreover, reintroduction of...
Tipo: Manuscript Palavras-chave: Cancer.
Ano: 2009 URL: http://precedings.nature.com/documents/3840/version/1
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Category of Metabolic-Replication Systems in Biology and Medicine Nature Precedings
I. C. Baianu.
Metabolic-repair models, or (M,R)-systems were introduced in Relational Biology by Robert Rosen. Subsequently, Rosen represented such (M,R)-systems (or simply MRs)in terms of categories of sets, deliberately selected without any structure other than the discrete topology of sets. Theoreticians of life's origins postulated that Life on Earth has begun with the simplest possible organism, called the primordial. Mathematicians interested in biology attempted to answer this important question of the minimal living organism by defining the functional relations that would have made life possible in such a minimal system- a grandad and grandma of all living organisms on Earth.
Tipo: Manuscript Palavras-chave: Biotechnology; Microbiology; Neuroscience; Bioinformatics; Earth & Environment; Evolutionary Biology.
Ano: 2012 URL: http://precedings.nature.com/documents/7045/version/1
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A comparative assessment of octanol-water partitioning and distribution constant estimation methods for perfluoroalkyl carboxylates and sulfonates Nature Precedings
Sierra Rayne; Kaya Forest.
New experimental data is available in the literature regarding the octanol-water distribution behavior of representative straight chain perfluoroalkyl carboxylate (PFCA) and sulfonate (PFSA) congeners. The current study provides the first investigation into the predictive ability of various software programs for estimating the corresponding octanol-water partitioning (log P) and distribution (log D) constants of PFCAs and PFSAs. Wide predictive variation was found within and between the various methods. Several programs were able to accurately estimate the log P/D fragmental contributions of a -CF~2~- group for PFCAs, as well as the associated Gibbs free energies for partitioning into octanol from water due to the hydrophobic character of the...
Tipo: Manuscript Palavras-chave: Chemistry; Earth & Environment.
Ano: 2009 URL: http://precedings.nature.com/documents/3282/version/2
Registros recuperados: 2.284
Primeira ... 107108109110111112113114115 ... Última
 

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