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| Registros recuperados: 255 | |
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| Slavov,S.N.; Vilar,F.C.; Wagatsuma,V.M.D.; Santana,R.C.; Machado,A.A.; Fonseca,B.A.L. da; Kashima,S.; Covas,D.T.. |
| The emergence of ganciclovir (GCV) resistance during the treatment of human cytomegalovirus (HCMV) infection is a serious clinical challenge, and is associated with high morbidity and mortality. In this case report, we describe the emergence of two consecutive mutations (A594V and L595W) related to GCV resistance in a patient with HCMV retinitis and long-term HIV progression after approximately 240 days of GCV use. Following the diagnosis of retinitis, the introduction of GCV did not result in viral load reduction. The detected mutations appeared late in the treatment, and we propose that other factors (high initial HCMV load, previous GCV exposure, low CD4+ cell count), in addition to the presence of resistance mutations, may have contributed to the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human cytomegalovirus; HCMV; Ganciclovir; Resistance; AIDS. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900777 |
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| Elias,L.L.K.; Clark,A.J.L.. |
| Adrenal glucocorticoid secretion is regulated by adrenocorticotropic hormone (ACTH) acting through a specific cell membrane receptor (ACTH-R). The ACTH-R is a member of the G protein superfamily-coupled receptors and belongs to the subfamily of melanocortin receptors. The ACTH-R is mainly expressed in the adrenocortical cells showing a restricted tissue specificity, although ACTH is recognized by the other four melanocortin receptors. The cloning of the ACTH-R was followed by the study of this gene in human diseases such as familial glucocorticoid deficiency (FGD) and adrenocortical tumors. FGD is a rare autosomal recessive disease characterized by glucocorticoid deficiency, elevated plasma ACTH levels and preserved renin/aldosterone secretion. This... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ACTH receptor; Resistance; Mutation; Transfection. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000015 |
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| d'Azevedo,Pedro Alves; Dias,Cícero Armídio Gomes; Lemos,Sibele Krebs; Bittencourt,José Augusto Ferreira; Teixeira,Lúcia Martins. |
| Resistance to several classes of antimicrobial agents is a remarkable characteristic of enterococcal strains increasingly reported worldwide. Information about strains isolated in the southern region of Brazil is still limited. In this study, a total of 455 consecutive enterococcal isolates recovered from patients living in Porto Alegre, Brazil, were identified at species level and evaluated for their antimicrobial susceptibilities by agar diffusion testing. The most frequent species was E. faecalis (92.8%), followed by E. faecium (2.9%), E. gallinarum (1.5%), E. avium (1.1%), E. hirae (0.7%), E. casseliflavus (0.4%), E. durans (0.4%), and E. raffinosus (0.2%). According to the results of disk tests 62.0% of the strains were resistant to tetracycline,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enterococcal; Antimicrobial susceptibility; Resistance. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000200005 |
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| Otth,Laura; Solís,Gabriela; Wilson,Myra; Fernández,Heriberto. |
| The susceptibility of 50 strains of Arcobacter butzleri isolated from chicken liver [12], mussels [18], river water [6] and bovine [5], duck [2] and pelicans [7] feces to mercury (Hg), chromium (Cr), silver (Ag), nickel (Ni), cobalt (Co), iron (Fe), manganese (Mn), molybdenum (Mo) and lead (Pb) was determined.All the strains were resistant to Mo, Mn, Ni, Co, Pb and Fe and susceptible to Hg, Ag and Cr. MIC values showed high variability, indicating a non homogeneous behavior among the strains. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arcobacter butzleri; Heavy metals; Resistance. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822005000300015 |
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| Bonesso,Mariana Fávero; Marques,Silvio Alencar; Camargo,Carlos Henrique; Fortaleza,Carlos Magno Castelo Branco; Cunha,Maria de Lourdes Ribeiro de Souza da. |
| The aim of this study was to determine the prevalence of Staphylococcus aureus and risk factors for the acquisition of MRSA (Methicillin Resistant Staphylococcus aureus) as the main cause of skin and soft tissue infections. S. aureus were characterized for the presence of PVL, TSST-1 and mecA genes. SCCmec typing was carried out in mecA positive strains and PFGE was performed only in these strains. During the study period, 127 outpatients attending a dermatology clinical the Botucatu Medical School, a regional tertiary hospital in Botucatu, Sao Paulo, Brazil, were diagnosed with active skin infections. A total 66 (56.9%) S. aureus strains were isolated. The methicillin resistance gene mecA was detected in seven (10.6%) S. aureus strains. The SCCmec types... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Staphylococcus aureus; Resistance; Skin infections; Virulence; Epidemiology. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400034 |
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| Wang,Su; Han,Li-Zhong; Ni,Yu-Xing; Zhang,Yi-Bo; Wang,Qun; Shi,Da-Ke; Li,Wen-Hui; Wang,Yi-Chen; Mi,Chen-Rong. |
| Abstract Surveillances and interventions on antibiotics use have been suggested to improve serious drug-resistance worldwide. Since 2007, our hospital have proposed many measures for regulating surgical prophylactic antibiotics (carbapenems, third gen. cephalosporins, vancomycin, etc.) prescribing practices, like formulary restriction or replacement for surgical prophylactic antibiotics and timely feedback. To assess the impacts on drug-resistance after interventions, we enrolled infected patients in 2006 (pre-intervention period) and 2014 (post-intervention period) in a tertiary hospital in Shanghai. Proportions of targeted pathogens were analyzed: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus spp. (VRE),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Surgical prophylactic antibiotics; Intervention; Resistance; Nosocomial infection. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000300552 |
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| Brandolt,Tchana Martinez; Klafke,Gabriel Baracy; Gonçalves,Carla Vitola; Bitencourt,Laura Riffel; Martinez,Ana Maria Barral de; Mendes,Josiara Furtado; Meireles,Mário Carlos Araújo; Xavier,Melissa Orzechowski. |
| Abstract Vulvovaginal candidiasis (VVC) is an infection of the genital mucosa caused by different species of the genus Candida. Considering the lack of data on this topic in the south of Brazil, this study aimed to assess the prevalence of Candida spp. in the cervical-vaginal mucosa of patients treated at a university hospital in southern Rio Grande do Sul, as well as the etiology and the susceptibility of the isolates against fluconazole, itraconazole, miconazole and nystatin. Samples were collected at the gynecology clinic of the Federal Hospital of the University of Rio Grande, and the isolates were identified using phenotypic and biochemical tests. The susceptibility analysis was performed according to the CLSI M27-A2 protocol. Of the 263 patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vulvovaginal candidiasis; Antifungal; Susceptibility; Resistance. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000100145 |
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| Azevedo,Paola Aparecida Alves; Furlan,João Pedro Rueda; Oliveira-Silva,Mariana; Nakamura-Silva,Rafael; Gomes,Carolina Nogueira; Costa,Karen Regina Carim; Stehling,Eliana Guedes; Pitondo-Silva,André. |
| ABSTRACT Enterobacter cloacae and E. aerogenes have been increasingly reported as important opportunistic pathogens. In this study, a high prevalence of multi-drug resistant isolates from Brazil, harboring several β-lactamase encoding genes was found. Several virulence genes were observed in E. aerogenes, contrasting with the E. cloacae isolates which presented none. |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Enterobacter cloacae; Enterobacter aerogenes; Virulence; Resistance. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000500224 |
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| Registros recuperados: 255 | |
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