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| Registros recuperados: 1.286 | |
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| Betim,Fernando Cesar Martins; Oliveira,Camila Freitas de; Souza,Angela Maria de; Szabo,Ellis Marina; Zanin,Sandra Maria Warumby; Miguel,Obdulio Gomes; Miguel,Marilis Dallarmi; Dias,Josiane de Fátima Gaspari. |
| The present study was undertaken to assess the potential uses of the essential oil obtained from Ocotea nutans (Nees) Mez. The hydrodistilled essential oil from O. nutans leaves was analyzed by gas chromatography-mass spectrometry. Fifty-eight compounds representing 87,29% of the total leaf essential oil components were identified, of which biciclogermacrene(11.41%), germacrene-D (4.89%), bisabolol-11-ol(3.73%) and spathulenol (3.71%) were the major compounds. The essential oil from O. nutans were tested for antibacterial activity using the minimum inhibitory concentracion (MIC) method, Artemia salina method, larvicidal activity in Aedes aegypti, and antioxidant capacity.The antioxidant activity measured by the phosphomolybdenum complex and Prussian blue... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ocoteanutans/essential oil/evaluation; Antioxidant capacity; Aedesaegypti; Toxic potential. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100513 |
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| Haq,Inamul; Ismail,Mohammad; Khan,Fahadullah; Khan,Qasim; Ali,Zahid; Noor,Sidra. |
| Hospitalized patients with left ventricular failure (LVF) are at high risk for potential drug-drug interactions (pDDIs) and its related adverse effects owing to multiple risk factors such as old age, comorbidities and polypharmacy. This cross-sectional study conducted in two tertiary care hospitals aim to identify frequency, levels and predictors of pDDIs in LVF patients. Data about patients’ demographic, hospital stay, medication therapy, sign/symptoms and laboratory test results were collected for 385 patients with LVF. Micromedex Drug-Reax® was used to screen patients’ medication profiles for pDDIs. Overall prevalence and severity-wise prevalence of pDDIs were identified. Chi-square test was performed for comparative analysis of various variables.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Left ventricular failure; Heart diseases; Potential drug-drug interactions; Drug interactions; Patients safety; Rational drug use. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100589 |
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| Goebel,Karin; Sato,Mayumi Eliza Otsuka; Souza,Dayse Fernanda de; Murakami,Fábio Seigi; Andreazza,Itamar Francisco. |
| In order for the pharmacological action of a topical dermal drug product to occur, the drug must first be released from the vehicle to be available to penetrate the skin layers and reach the site of action. Drug release is mainly dependent on the characteristics of the formulation. Currently, to register a generic or a similar drug product in Brazil performance testing of topical drug products for local action is not required. In this context, this aim of this study was to evaluate the in vitro release of commercial diclofenac diethylamine gel products available on the Brazilian pharmaceutical market, using the vertical diffusion cell method. Factors which may influence the test, such as the type of membrane used, and the effect of the formulation... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: In vitro release test; Diclofenac diethylamine/gel; Synthetic membranes; Generic semisolid drug products. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200003 |
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| Bomfim,Marcus Vinicius Justo; Abrantes,Shirley de Mello Pereira; Zamith,Helena Pereira da Silva. |
| A ε-caprolactama (CAP) é um monômero precursor de polímeros denominados nylon 6. Esses polímeros destinam-se à produção de tapetes, vestuário e materiais plásticos tais como equipamentos, sistemas e componentes automotivos, conectores, além de embalagens plásticas. Resíduos de CAP podem migrar de embalagens plásticas de nylon 6 para os alimentos. Diante disso, foi de interesse realizar uma revisão dos efeitos relativos à exposição à CAP e o seu impacto sobre a saúde humana. Estudos epidemiológicos indicam a possibilidade da CAP causar inflamações oculares e cutâneas, além de irritações no sistema respiratório. Pode ocorrer ainda hipotensão, taquicardia, palpitações, rinorréia, ressecamento nasal, efeitos geniturinários e sobre a reprodução como distúrbios... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caprolactama/aspectos toxicológicos; Toxicodinâmica; Mutagenicidade; Carcinogenicidade; Embalagens plásticas/efeito tóxico. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100004 |
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| Magalhães,Wagner Vidal; Baby,André Rolim; Velasco,Maria Valéria Robles; Pereira,Deborah Martin Mendes; Kaneko,Telma Mary. |
| The aim of this work was to evaluate the innovative performance of herbal extracts applied in cosmetics area, based on information collected from Brazilian, American and European patent banks. Analysis were carried out to evaluate the number of patent deposits from each database, the patent applicants profiles, the companies with most patent applications, and also the main uses of herbal extracts in cosmetics. Based on the results achieved, the number of patents filed at the Brazilian patent bank is much lower than that observed in American and European patent banks. Although the number of patents is limited, the analysis indicated a range of cosmetic applications that acts according to the international market trend, represented by a large number of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cosmetics/patenting; Plant extract/use in cosmetics. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400005 |
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| Salgado,Ana Cristina Gomes Barros; Silva,Alexandra Maria Nunes Nogueira da; Machado,Marta Cristina Jorge Cabral; Duarte,Maria Aida da Silva Costa; Ribeiro,Helena Margarida de Oliveira Marques. |
| Dermatological inflammatory diseases such as atopic dermatitis, psoriasis and seborrhoeic dermatitis often affect the scalp and the eyebrows. Although there are many dosage forms available, these are particularly critical anatomic regions for application of topical formulations because of the presence of hair. Lotions are therefore the recommended type of drug delivery system for these areas. The presence of hair may limit the application and thus the acceptability of the formulation and its compliance. Because of its low apparent viscosity, lotion application is unpleasant. Gels, given their consistency and adhesiveness, are a suitable alternative to lotions in this situation. The aim of this study was to formulate a stable gel containing mometasone... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dermatitis/treatment; Mometasone furoate; Gel/development; Gels/stability; Skin permeation/in vitro study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100012 |
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| Yang,Zhenlei; Wang,Longmei; Tian,Liu; Zhang,Xiuping; Huang,Guihua. |
| Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegradable PLGA (poly(lactic-co-glycolic acid)) microspheres (TDF-PLGA-MS) via emulsification-solvent evaporation. The resulting microspheres were processed into pulmonary inhalant by freeze drying. The TDF-PLGA-MS was spherical and uniform, with an average particle diameter ~10.29 µm. The encapsulation efficiency and drug loading yield of TDF-PLGA-MS were 81.68% and 8.52%, respectively. The investigation of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pulmonary arterial hypertension; Tadalafil; PLGA; Microspheres; Pulmonary administration; Micromeritic; In vitro release; Pharmacokinetic; Tissue distribution. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100587 |
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| Almeida,Tamires Cunha; Seibert,Janaina Brandão; Almeida,Sávio Henrique de Souza; Amparo,Tatiane Roquete; Teixeira,Luiz Fernando de Medeiros; Barichello,Jose Mario; Postacchini,Bruna Bueno; Santos,Orlando David Henrique dos; Silva,Glenda Nicioli da. |
| Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Cytotoxic activity; F127®; Polymeric micelles; Resveratrol. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100567 |
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| Pandey,Saurabh; Pandey,Preeti; Mishra,Durgesh; Singh,Umesh Kumar. |
| A stability-indicating high-performance liquid chromatographic (HPLC) method was developed with short run time and validated for the assay of process related impurities of pantoprazole in bulk form. Resolution of drug, its potential impurities and degradation products were achieved on a Hypersil ODS column utilizing a gradient with 0.01 M phosphate buffer of pH 7 and acetonitrile as eluent, at the detection wavelength of 290 nm. Flow rate was set at 1 mL min-1. The procedure was found to be specific, linear (r=0.999), recovery (97.9-103%), LOD (0.043-0.047 µgmL-1), LOQ (0.13-0.14 µgmL-1) and robust. Acceptable robustness indicates that the assay method remains unaffected by small but deliberate variations. Pantoprazole was found to degrade in acidic,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High performance liquid chromatography/qualitative analysis; High performance liquid chromatography/method development; Pantoprazole/forced degradation. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100019 |
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| Reis,Camila Borges dos; Boff,Daniele Schaab; Lima,Isabela Angeli de; Santos,Leandro Freire dos; Calvalcanti,Osvaldo Albuquerque; Bunhak,Élcio José. |
| ABSTRACT Polymeric films associating different concentrations of Eudragit(r) FS 30 D (EFS) and chondroitin sulfate (CS) were produced by casting for the development of a new target-specific site material. Formed films kept a final polymer mass of 4% (w/v) in the following proportions: EFS 100:00 CS (control), EFS 95:05 CS, EFS 90:10 CS and EFS 80:20 CS. They were analyzed for physical and chemical characteristics using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Raman spectroscopy. Furthermore, they were characterized by their water vapor permeability and degree of hydration at different conditions simulating the gastrointestinal tract. No chemical interactions were observed between CS and EFS, suggesting only a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polymeric films/smelting process; Eudragit(r) FS 30 D/modified delivery; Chondroitin Sulfate; Polymeric coating.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400635 |
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| Registros recuperados: 1.286 | |
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