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| Registros recuperados: 28 | |
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| Ito,Felicia Megumi; Mena,Ana Elisa Maciel; Marques,Maria Rita; Lima,Dênis Pires de; Beatriz,Adilson. |
| The present study aimed to evaluate the ability for biotransformation of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione (1) and two synthetic derivatives by the saprobe fungus Mucor ramosissimus Samutsevitsch. Products from oxidation, isomerization and, regioselective and enantioselective reduction were achieved. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mucor ramosissimus; Biotransformation; Diels-Alder adduct. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000300019 |
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| Mercimek,Hatice Aysun; Dincer,Sadik; Guzeldag,Gulcihan; Ozsavli,Aysenur; Matyar,Fatih; Arkut,Afet; Kayis,Fikret; Ozdenefe,Melis Sumengen. |
| Degradation of 2,4,6-trinitrotoluene (TNT), a nitroaromatic explosive found in the soil and ground water, was investigated using Pseudomonas aeruginosa in in vitroexperiments. Biodegradable abilitiy of this bacteria was performed with 50 and 75 mg L−1 TNT concentrations in a defined liquid medium for 96 h time period. Treatment of TNT in supernatant samples taken at 0, 6, 12, 24, 48, 72 and 96 h from agitated vessels was followed by reverse-phase high-performance liquid chromatography (HPLC). In cultures supplemented with 50 and 75 mgL−1 TNT, after 96 h of incubation 46% and 59% reduction were detected respectively. Two metabolites as degradation intermediates with nitrite release into the medium, 2,4-dinitrotoluene (2,4-DNT) and 4-aminodinitrotoluene... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pseudomonas sp; Biotransformation; Nitroaromatic explosives; TNT. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100103 |
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| Andrade,Carolina Horta; Freitas,Lenis Medeiros de; Oliveira,Valéria de. |
| From the identification of HIV as the agent causing AIDS, to the development of effective antiretroviral drugs, the scientific achievements in HIV research over the past twenty-six years have been formidable. Currently, there are twenty-five anti-HIV compounds which have been formally approved for clinical use in the treatment of AIDS. These compounds fall into six categories: nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors (NtRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), cell entry inhibitors or fusion inhibitors (FIs), co-receptor inhibitors (CRIs), and integrase inhibitors (INIs). Metabolism by the host organism is one of the most important determinants of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIDS/treatment; Drugs/anti-HIV; Drugs/metabolism; Antiretroviral drugs; Biotransformation. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200003 |
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| Ahmad,Saeed; Khaliq,Farhan Hameed; Madni,Asadullah; Shahid,Muhammad Nabeel; Pervaiz,Irfan. |
| In the present research, the steroidal anti-asthmatic drug beclomethasone dipropionate was subjected to microbial biotransformation by Aspergillus niger. Beclomethasone dipropionate was transformed into various metabolites first time from microbial transformation. New drug metabolites produced can act as new potential drug molecules and can replace the old drugs in terms of safety, efficacy, and least resistance. They were purified by preparative thin layer chromatography technique, and their structures were elucidated using modern spectroscopic techniques, such as 13C NMR, 1H NMR, HMQC, HMQC, COSY, and NOESY, and mass spectrometry, such as EI-MS. Four metabolites were purified: (i) beclomethasone 17-monopropionate, (ii) beclomethasone 21-monopropionate,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-asthmatics; Aspergillus niger/use in biotransformation; Beclomethasone dipropionate/microbial biotransformation; Steroids/microbial transformation; Biotransformation. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400903 |
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| Registros recuperados: 28 | |
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