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| Registros recuperados: 382 | |
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| Petr Lokhov. |
| Immunization with cancer cells is of great demand in anti-cancer therapy. However, current cellular vaccines are inefficient and there are questions regarding their overall safety. We report a simple and straightforward approach for improving of cellular cancer vaccines. Through treatment of cancer cell cultures with purified protease, it is possible to make preparations of cell-surface antigens that are free of intracellular content and contain two orders-of-magnitude less protein than the whole lysate of an equivalent number of cancer cells. Despite this difference in total protein content, protease-generated preparations stimulate anti-cancer responses from immune cells better those stimulated with cancer cells themselves. The composition of collected... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4356/version/1 |
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| Gabriel Leitner; Ana-Maria Anug; Uzi Merin; Nissim Silanikove. |
| *Background*
Repeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species.

*Methodology/Principal Findings*
We took an advantage of a rare event in the normal modern dairy farming: A cow that was false-positively identified as being pregnant was "dried up" (i.e., induced into involution) conventionally about 60 before her expected parturition. This cow was culled, and samples of her mammary gland tissue were examined for gross histology. In this study we demonstrate for the first time that modern dairy cow may undergo extensive obliteration of the... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Developmental Biology; Immunology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/846/version/2 |
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| Scott L. Carter; Matthew Meyerson; Gad Getz. |
| Interpretation of allelic copy measurements at polymorphic markers in cancer samples presents distinctive challenges and opportunities. Due to frequent gross chromosomal alterations occurring in cancer (aneuploidy), many genomic regions are present at homologous-allele imbalance. Within such regions, the unequal contribution of alleles at heterozygous markers allows for direct phasing of the haplotype derived from each individual parent. In addition, genome-wide estimates of homologue specific copy- ratios (HSCRs) are important for interpretation of the cancer genome in terms of fixed integral copy-numbers. We describe HAPSEG, a probabilistic method to interpret bi- allelic marker data in cancer samples. HAPSEG operates by partitioning the genome into... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6494/version/1 |
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| K Robb; S Stubbings; A Ramirez; U Macleod; J Austoker; J Waller; S Hiom; J Wardle. |
| *_Objective:_* To assess public awareness of cancer warning signs, anticipated delay, and perceived barriers to seeking medical advice in the British population. 
Methods: We carried out a population-based survey using face-to-face, computer-assisted interviews to administer the Cancer Awareness Measure (CAM), a newly-developed, validated measure of cancer awareness. The sample included 2216 adults (970 male and 1246 female) recruited as part of the Office for National Statistics Opinions Survey using stratified probability sampling.

*_Results:_* Awareness of cancer warning signs was low when open-ended (recall) questions were used and higher with closed (recognition) questions; but on either measure,... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3817/version/1 |
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| Michael E. Baker; Charlie Chandsawangbhuwana. |
| *Background.* The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ERs have been found in lamprey, a basal vertebrate, and amphioxus, a basal chordate. Motif analysis of these sequences provides an opportunity to investigate early events in the evolution of the ER.
*Results.* We used artificial intelligence-based software to construct twelve motifs specific to the estrogen-binding domain of ER[alpha] and ER[beta] in land vertebrates and teleosts. We mapped these ER-specific motifs onto the sequences of lamprey, amphioxus, invertebrate and selected vertebrate ERs and amphioxus, Ciona and human estrogen-related... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Developmental Biology; Ecology; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1542/version/2 |
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| Örjan Hallberg. |
| Incidence rates of several cancers, including melanoma of the skin and breast cancer, have increased since the middle of the 20th century in Western countries. Here, we developed a model for cancer incidence over time, when considering a suddenly increased cancer risk from an environmental change. A two parameter exponential function was used to simulate cancer risk over calendar time since birth, taking into account the time lapse since the environmental change took place. The calculated incidence for all age cohorts over calendar time was used to calculate the age-standardized rates. The best fit between calculated and reported age-standardized rates was sought by parameter variation. The model was tested using reported rates for melanoma and breast... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6779/version/1 |
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| Nobuoki Eshima; Minoru Tabata; Yasunori Higuchi; Shigeru Karukaya. |
| Human T-cell leukemia virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukemia. The male-to-female transmission is stronger than the reverse, so the carrier proportion of women is greater than that of men. On the other hand, since the mother-to-child transmission route via the breast-feeding is common for baby boys and girls, it has been thought the HTLV-I proportions of boys and girls are the same until now. A question arises as to whether the ‘innate protection powers against human virus’ are the same between males and females. We utilize HTLV-I infection blood donor data in 1995-1998 and case data of main infectious diseases such as influenza, mumps, herpangina, hand-hoot-and-mouse disease, chicken pox, etc. Blood... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Immunology; Microbiology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1987/version/2 |
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| Piotr Dittwald; Anna Gambin. |
| This document presents the original approach for estimating parameters of proteolysis process. Data used to fit the model are taken from mass
spectrometric experiments. For parameters estimation the Levenberg-Marquadt algorithm is used. The motivation for model is a hypothesis
that discrimination between cancer patients and healthy donors can be based on activity of peptide cleaving enzymes (i.e. peptidases). |
| Tipo: Manuscript |
Palavras-chave: Cancer; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4400/version/1 |
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| Diana D. E. Marco; Sergio S. A. Cannas; Marcelo M. A. Montemurro; Bo Hu; Shiyuan Cheng. |
| The invariance of some system properties over a range of temporal and/or spatial scales is an attribute of many processes in nature1, often characterised by power law functions and fractal geometry2. In particular, there is growing consensus in that fat-tailed functions like the power law adequately describe long-distance dispersal (LDD) spread of organisms 3,4. Here we show that the spatial spread of individuals governed by a power law dispersal function is represented by a clear and unique signature, characterised by two properties: A fractal geometry of the boundaries of patches generated by dispersal with a fractal dimension D displaying universal features, and a disrupted patch size distribution characterised by two different power laws. Analysing... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Ecology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/907/version/1 |
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| Masaki Miyamoto. |
| Using modern TV-endoscope equipment, we have experimented image processing in several ways. This time, we designed new image processing unit called “Color Subtracted Enhancement image processing unit”. This unit　was made by combining the RGB-Subtraction　image processing device with the color enhancement image processing device. The　RGB-subtraction device is an analogue unit that　enables us to remove the visible red, green and blue peaks from the image. We can subtract the images R-G, R-B, G-R, B-R, B-G simply by changing the switches. The color enhancement device (developed by Olympus optical corporation inc.) is a digital processing unit that lets us reinforce any of these colors. This... |
| Tipo: Poster |
Palavras-chave: Cancer. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2255/version/1 |
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| Valentin Mitin. |
| Any human organism is home to viruses and bacteria. However, viruses (as well as other intracellular parasites) are interested in continuous division of the host cells. Unlimited division of the host cells means unlimited expansion of the living space and possibility for unlimited multiplication of viral particles. For this, human Cell Cycle Regulation System has to be affected in such a way to induce unlimited division of host cells. The present work describes oncogenome`s model of cancer development, according to which, in order to stimulate cell division, viruses affect a gene (or several genes) during transduction of a signal for cell division from growth factor to cyclin/CDK system. At the same time, controlling gene (p53, RB etc.) function and a... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6322/version/1 |
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| Giovanni Ferrari; B D. Cook; Vitaly Terushkin; Giuseppe Pintucci; Paolo Mignatti. |
| VEGF and TGF-[beta]1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF-[beta]1 induces apoptosis. We have previously shown that VEGF / VEGF receptor-2 (flk-1) signaling mediates TGF-[beta]1 induction of apoptosis. This finding raised an important question: Does this mechanism stimulate or inhibit angiogenesis? Here we report that VEGF-mediated apoptosis is required for TGF-[beta]1 induction of angiogenesis. In vitro the apoptotic effect of TGF-[beta]1 on endothelial cells is rapid and followed by a long period in which the cells are refractory to apoptosis induction by TGF-[beta]1. Inhibition of VEGF / flk-1 signaling abrogates formation of vessel-like structures by TGF-[beta]1 with an... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1758/version/1 |
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| Larry Weiseenthal; Summer Williamson; Cindy Brunschwiler; Constance Rueff-Weisenthal. |
| Bähr and colleagues reported that 22 of 36 glioblastoma patients treated with bevacizumab showed tumor calcifications on 8 week post therapy follow up with MRI. Early tumor calcification strongly predicted for response, time to progression, and overall survival. The authors didn’t understand the mechanism, but speculated that it was vascular in nature. At the 13th International Anti-Angiogenic Symposium (2011), we presented our discovery of the phenomenon of massive calcium accumulation death, wherein MCAD occurred in endothelial cells (tumor, circulating, and HUVEC), in response to VEGF depletion by bevacizumab and other putative anti-angiogenic agents, but not in response to non-specific cytotoxins. In subsequent work, we have... |
| Tipo: Poster |
Palavras-chave: Cancer. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7069/version/1 |
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| Lopamudra Das Roy; Latha Pathangey; Teresa Tinder; Pinku Mukherjee. |
| Chronic inflammation is known to play a role in cancer initiation, promotion,and metastasis. However, the mechanism by which inflammation promotes metastasis is still unclear. We evaluated if chronic inflammation induced by autoimmune arthritis may contribute to increased breast cancer-associated metastasis. We report a three-fold increase in lung metastasis and a significant increase in the incidence of bone metastasis in the pro-arthritic mice compared to control mice. The metastatic breast tumors in turn augment the severity of arthritis resulting in a vicious cycle that increases both bone destruction and metastasis. Enhanced neutrophilic and granulocytic infiltration in lungs and bone of the pro-arthritic mice and subsequent increase in circulating... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2632/version/1 |
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| Wende Li; Farah S. Hosseinian; Arnold W. Hydamaka; Lynda Lowry; Trust Beta. |
| Consumption of fruits and vegetables is shown to be beneficial for protecting health and preventing some chronic diseases such as cancer, cardiovascular disease, and stroke. The positive health effects have been mainly due to the contributions of their natural antioxidant capacity. Chokecherry (Prunus virginiana), a unique fruit, is a member of the Rose family and native to North America. Here we demonstrate that chokecherry fruit with strong antioxidant capacity is available in Manitoba, and that its potent antioxidant potential can be developed for health benefits in value-added applications.These findings are useful for developing novel value-added antioxidant products from chokecherry because of its phytochemical profile associated with health... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Chemistry; Plant Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1529/version/1 |
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| Registros recuperados: 382 | |
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