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| Registros recuperados: 25 | |
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| Kliemann,Mariele; Prá,Daniel; Müller,Luiza L.; Hermes,Liziane; Horta,Jorge A.; Reckziegel,Miriam B.; Burgos,Miria S.; Maluf,Sharbel W.; Franke,Silvia I.R.; Silva,Juliana da. |
| The risk of developing cardiovascular disease (CVD) is related to lifestyle (e.g. diet, physical activity and smoking) as well as to genetic factors. This study aimed at evaluating the association between CVD risk factors and DNA damage levels in children and adolescents. Anthropometry, diet and serum CVD risk factors were evaluated by standard procedures. DNA damage levels were accessed by the comet assay (Single cell gel electrophoresis; SCGE) and cytokinesis-blocked micronucleus (CBMN) assays in leukocytes. A total of 34 children and adolescents selected from a population sample were divided into three groups according to their level of CVD risk. Moderate and high CVD risk subjects showed significantly higher body fat and serum CVD risk markers than low... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiovascular diseases; Micronucleus test; Comet assay; Diet; Anthropometry; Child; Adolescent. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000300025 |
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| VILELA,THAIS C.; LEFFA,DANIELA D.; DAMIANI,ADRIANI P.; DAMAZIO,DAIANE DAL COL; MANENTI,ALINE V.; CARVALHO,TIAGO JOSÉ G.; RAMLOV,FERNANDA; AMARAL,PATRICIA A.; ANDRADE,VANESSA M. DE. |
| Abstract Hibiscus acetosella was shown to exert beneficial effects in humans and animal models however, the effects of this plant on DNA are unknown. The aim of this study was to determine the antigenotoxic and antimutagenic effects of H. acetosella extracts on alkylating agent methyl methanesulfonate (MMS) in vivo in mice. Initially, we performed analysis of phenolic compounds in extracts of H. acetosella by high-performance liquid chromatography (HPLC). Next, mice were divided into 8 groups and treated with distilled water or plant extract (0.1 ml/10 g) by gavage for 15 days, followed by intraperitoneal (ip) administration of saline solution or MMS (40 mg/Kg b.w) on day 16. Caffeic acid, following by gallic acid, gallocatechin, coumaric acid, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hibiscus acetosella; Antigenotoxicity; Comet assay; Antimutagenicity; Micronucleus test. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603165 |
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| Registros recuperados: 25 | |
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