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| Michele Magrane; UniProt Consortium. |
| UniProtKB provides the scientific community with a comprehensive collection of protein sequence records containing extensive curated information including functional and sequence annotation. This information is derived from a variety of sources such as scientific literature and sequence analysis programs as well as data imported from automatic annotation systems and external databases. To allow users to ascertain the origin of each data item in a UniProtKB record, an evidence attribution system is being introduced which links each piece of information to its original source. This system allows users to trace the origin of all information, to differentiate easily between experimental and computational data, and to assess data reliability. The current system... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3129/version/1 |
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| Scott L. Carter; Matthew Meyerson; Gad Getz. |
| Interpretation of allelic copy measurements at polymorphic markers in cancer samples presents distinctive challenges and opportunities. Due to frequent gross chromosomal alterations occurring in cancer (aneuploidy), many genomic regions are present at homologous-allele imbalance. Within such regions, the unequal contribution of alleles at heterozygous markers allows for direct phasing of the haplotype derived from each individual parent. In addition, genome-wide estimates of homologue specific copy- ratios (HSCRs) are important for interpretation of the cancer genome in terms of fixed integral copy-numbers. We describe HAPSEG, a probabilistic method to interpret bi- allelic marker data in cancer samples. HAPSEG operates by partitioning the genome into... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6494/version/1 |
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| Yury L. Voytekhovsky. |
| Polyhedral forms are extremely widespread both in animate and inanimate nature. Thus, crystals occur as polyhedra only. Besides, these forms are quite common with various primitive organisms, i.e. icosahedral viruses, radiolaria and algae. Here we discuss the cases of exotic Boxfish and Porcupinefish. The specific morphology of the Boxfish reveals in polygonal osseous blades, covering its body. As for the Porcupinefish, its polyhedral approximation was observed via certain geometrical techniques applied. Namely, their spine bases were considered the Delaunay point (R, r)-systems. Consequently, the respective Dirichlet tiling proved to be quasifullerenes and analogous to the Boxfish morphology. This unexpected geometrical dualism of the two families... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2191/version/1 |
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| Bidhan C. Bandyopadhyay; Lina Chakrabarti; Mrinal K. Poddar. |
| Amounts of dietary protein as well as the duration of its supplementation are critical
factors that correlate with the hypothalamic GABAergic activity and immune function
during aging. Here we evaluate the effect of low (5%) and high (40%) protein diet on the
functional state of hypothalamic GABA receptor in the aging brain in albino rats. Longterm
(LT; for 30 consecutive days) supplementation of low protein diet (LDP) retarded
the age-associated (3 to 18 months) (a) loss of both low and high affinity hypothalamic
GABA receptor sensitivity and (b) increase of high affinity GABA receptor density.
Short-term (ST; for 7 consecutive days)... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2284/version/1 |
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| Haoran H. Wang; Mary X. Gao; Sato Kenzo; Kazumitsu Hirai. |
| In all organisms, messenger-directed protein synthesis is catalyzed by ribonucleoprotein particles called ribosomes. A ribosome is typically composed of one small and one large subunit which contain one short (18S) and one long (28S) rRNAs, respectively. Surprisingly, in this study, three similar size rRNAs (18-21S) were revealed in the electrophoresis profile of the total RNAs of tapeworm _Spirometra erinaceiuropaei_. Northern blot analysis shows that one of the three bands belongs to 18S rRNA, and the other two bands are of 28S rRNAs, implying structurally distinct ribosomes in this intermediate animal. Furthermore, similar, but not identical profiles were observed in two other tapeworms _Diphyllobothrium hottai_ and _Diphyllobothrium Nipponkaiizeme_.... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Microbiology; Molecular Cell Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2608/version/2 |
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| Wei Sheng Zeng; Shou Zheng Tang. |
| To implement monitoring and assessment of national forest biomass, it is becoming the trend to develop generalized single-tree biomass models suitable for large scale forest biomass estimation. Considering that the theoretical biomass allometric model developed by West et al. [1,2] was statistically different from the empirical one, the two parameters in the most commonly used biomass equation M=aDb were analyzed in this paper. Firstly, based on the knowledge of geometry, the theoretical value of parameter b was deduced, i.e., b=7/3(~2.33), and the comparison with many empirical studies conducted throughout the globe indicated that the theoretical parameter could describe soundly the average allometric relationship between aboveground biomass M and D... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6704/version/2 |
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| Josh Merel; Gasper Tkacik; Adam Gifford; Jason Prentice; Vijay Balasubramanian. |
| Summary: Recent electrophysiology recordings in macaque V4/IT suggest that single neuron response to synthetic closed contours can be largely captured by models which only consider a small number of contour fragments (Brincat and Connor 2004). Motivated by this experimental work, we sought firstly to characterize the statistics of contour fragments in natural scenes, and secondly to generate synthetic images which reflect the measured contour-fragment statistics.

To detect contour fragments, we defined a set of feature detectors which respond only in the presence of two edges co-occurring at a fixed relative angle – implemented as a logical ‘AND’ of two Gabor-like, laplacian-of-gaussian... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6366/version/1 |
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| K Robb; S Stubbings; A Ramirez; U Macleod; J Austoker; J Waller; S Hiom; J Wardle. |
| *_Objective:_* To assess public awareness of cancer warning signs, anticipated delay, and perceived barriers to seeking medical advice in the British population. 
Methods: We carried out a population-based survey using face-to-face, computer-assisted interviews to administer the Cancer Awareness Measure (CAM), a newly-developed, validated measure of cancer awareness. The sample included 2216 adults (970 male and 1246 female) recruited as part of the Office for National Statistics Opinions Survey using stratified probability sampling.

*_Results:_* Awareness of cancer warning signs was low when open-ended (recall) questions were used and higher with closed (recognition) questions; but on either measure,... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3817/version/1 |
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| Gil-Mi Ryu; Pamela Song; Kyu-Won Kim; Kyung-Soo Oh; Jong Hun Kim. |
| We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and may constitute a proportion of the mechanisms by which genetic variations cause individual differences or diseases. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases. |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2079/version/1 |
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| Huilei Xu; Avi Ma'ayan. |
| Results from multivariate molecular biological experiments become increasingly complex. Hence, the challenge of projecting high-dimensional data onto few dimensions for effective data visualization is becoming increasingly important in Systems Biology. Effective data visualization can summarize the activity of many variables over time as well as display relationships between variables. Dynamic interactive visualization tools can provide scientists with ways of visually identifying relationship and patterns, and improve communication of results on the web and in presentations. For this, interactive systems with animation have great potential since they add dimensions to static images limited to two dimensions. Interactivity and animation is particularly... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Molecular Cell Biology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3074/version/1 |
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| Martin Piskacek. |
| Recently reported, 9aaTAD transcription factors p53, VP16, MLL/ALL, E2A, HSF1, NF-IL6, NFAT1 and NF-kB interact directly with the general coactivator CBP/p300 aside from already referred TAF9. All four domains of CBP/p300 - KIX, TAZ1, TAZ2 and IBiD provide multiple interactions with 9aaTADs, e.g. p53. Annotation of predicted 9aa TAD using Pattern search ScanProsite on ExPASy and relevant experimental data are listed. |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3984/version/1 |
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| Christine Wandelt; Esteban Alcalde; Katrina Hayter; Gaston Legris; Beth J. Patterson; Bruno Tinland; Pieter Windels. |
| The objective of general surveillance is to identify the occurrence of unanticipated adverse effects of GM crops on human health or the environment that were not covered in the environmental risk assessment. EuropaBio is harmonizing an approach to non-hypothesis driven post-market environmental monitoring relating to the cultivation of different GM crops, comprising a farmer questionnaire, existing surveillance systems as well as other data sources. As an unanticipated adverse effect is most likely to occur where the level of environmental exposure is highest, general surveillance focuses on the agricultural environment and those agronomic zones that are representative of commercial GM crop cultivation. The farmer questionnaire is one element of the... |
| Tipo: Presentation |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4451/version/1 |
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| Lung-Hao Tai; Anthony M. Zador. |
| How does attention modulate sensory representations? In order to probe the underlying neural mechanisms, we established a simple rodent model of modality-specific attention. Here we describe results of experiments in freely moving rats in which we have used tetrodes to record neural responses in primary auditory cortex (area A1) while subjects performed this behavior.

Subjects were first trained to perform distinct auditory and olfactory two alternative forced-choice (2AFC) tasks. Training and testing were conducted in a custom three-poke computer-controlled behavioral apparatus. Subjects initiated trials with a center-poke, which triggered presentation of a tone (either 5 or 15 Hz), an odor (either R(-)-2-Octanol or... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2354/version/1 |
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| Allen Institute for Brain Science; Emily M. Wright; Lydia L. Ng; Angela L. Guillozet-Bongaarts. |
| This report contains a summary of expression patterns for genes that are enriched in the Purkinje cell layer (CBXpu) of the cerebellum. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project. The structure's location and morphological characteristics in the mouse brain are described using the Nissl data found in the Allen Reference Atlas. Using an established algorithm, the expression values of the CBXpu were compared to the values of its larger parent structure, in this case the cerebellar cortex, for the purpose of extracting regionally selective gene expression data. The highest ranking genes were manually curated and verified. 50 genes were then selected and compiled for expression analysis. The experimental... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2200/version/1 |
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| Roderic Page. |
| The fact that all living organisms are related by common descent is one of the central principles of modern biology. Since the early 1990's the amount of data available to evolutionary biologists has exploded, and Elsevier’s journal _Molecular Phylogenetics and Evolution_, has become the largest single publisher of evolutionary trees (phylogenies). These trees and their supporting data potentially form a tremendous resource for biologists, with applications in genomics, evolutionary biology, biodiversity, and public health. However, most published trees are not available in any public database, but instead languish as images, "locked up" in the pages of journals. A long term solution to this problem is to invert the... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2217/version/1 |
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| Jakob Suckale; Michele Solimena. |
| Taken together the Islets of Langerhans form a nutrient sensing network spread throughout the pancreas. They are tightly connected to the source organ - the intestine - and the target organs - liver, muscle, and fat cells. The expression of a unique set of proteins enables [beta] cells, the most frequent islet cell type, to detect elevated blood glucose levels and secrete insulin accordingly. Neighbouring [beta]-cells achieve tighter regulation of glucose-induced insulin secretion by coordination through cell surface proteins. They also adjust their secretory pathway capacity and flow to avoid being damaged. The immediate reaction of the [beta] cell to nutrients is regulated by translational mechanisms, while longer term adaptations involve... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1724/version/1 |
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| Marco Antonio M. A. Russo; Sonja Veljovic-Jovanovic; Adalgisa Belligno. |
| The aim of this work was to study, as a function of the different availability of nitrogen in the reduced form, mineral and organic, the induction of the synthesis of some ROS-scavenging molecules and the evolution of some enzymatic activities such as ascorbate peroxidase (APX) and polyphenoloxidase (PPO). 
Chicory seedlings were grown in nutritive solution for 35 days in controlled conditions. On the 14th day, one third of the plants was transferred into a nutritive solution containing (NH4)2SO4 60 mM, one third was transferred into a medium containing Urea 60 mM, and the remaining was let grow into the nutrition solution, as a control. Three samplings of leaves were performed, respectively after 21, 28 and 35 days of... |
| Tipo: Manuscript |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4173/version/1 |
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| Registros recuperados: 3.453 | |
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