|
|
|
| Registros recuperados: 45 | |
|
| |
|
|
| Karimi,Soroush; Moradipour,Pouran; Azandaryani,Abbas Hemati; Arkan,Elham. |
| In the present study, a mucoadhesive non-woven fiber mat (d= 116 nm) was fabricated by the electrospinning method using chitosan (80% Wt), polyethylene oxide (10% Wt), cysteine (4% Wt) and drugs (6% Wt), respectively. In addition, a comparative study was conducted to define effect of drugs and mucoadhesive agent on the nanofiber formation. FTIR, SEM, DSC and DMA were used to investigate the chemical and physical properties of the nanofibers. In vitro release of the drugs was assessed over a 48-hour period by the total immersion method. Release data were fitted to kinetic models, including the zero-order, first-order, Higuchi matrix, and Hixson-Crowell. Zone inhibition investigations were used to describe the inhibition content of vancomycin and amphotericin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mucoadhesive; Vancomycin; Amphotericin-B; Electrospinning; Aphthous; Chitosan. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100521 |
| |
|
|
| Elsayed,Mahmoud M. A.. |
| Tolmetin sodium (TS) is a powerful non-steroidal mitigating drug for the treatment of rheumatoid joint inflammation, osteoarthritis, and adolescent rheumatoid joint pain. In addition to its gastrointestinal (GIT) problems, TS has a short biological half-life (1 hr). In a trial to overcome these side effects and control the rate of (TS) release, chitosan coated alginate microspheres are recommended. A Box-Behnken experimental design was employed to produce controlled release microspheres of TS in the sodium alginate and chitosan copolymers (Alg-Ch) by emulsification internal gelation methodology. The effect of critical formulation variables namely, drug to polymer ratio (D:P ratio), speed of rotation and span 80% on drug encapsulation efficiency (% EE),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tolmetin Sodium; Controlled Release; Alginate; Chitosan; Response Surface. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100604 |
| |
|
| |
|
|
| Duarte,Dirliane Santos; Nascimento,José Augusto de Almeida; Britto,Douglas de. |
| ABSTRACT Given the potentiality of nanoparticles (NP) to load substances as active principle of drugs, cosmetics and food, there is interest in increasing its production. Particularly in the agroindustrial area, the byproducts are source of functional compounds that must be stabilized by encapsulation, for example, to allow its application. Considering the amount of generated byproducts, it is necessary to understand the encapsulation synthesis in a high scale dimension. In this way, the active compounds vitamin C (from the byproduct of the acerola processing) and polyphenols (from the byproduct of grape processing) were nanoencapsulated into chitosan NP at three reactional volumes: 0.1; 1.0 and 10.0 dm3. The NP were characterized for yield, particle size,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vitamin C; Polyphenols; Byproduct; Chitosan. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542019000100406 |
| |
| Registros recuperados: 45 | |
|
|
|
