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Registros recuperados: 48
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The use of standard methodology for determination of antifungal activity of natural products against medical yeasts Candida sp and Cryptococcus sp BJM
Scorzoni,Liliana; Benaducci,Tatiane; Almeida,Ana Marisa Fusco; Silva,Dulce Helena Siqueira; Bolzani,Vanderlan da Silva; Gianinni,Maria José Soares Mendes.
Methodology for testing natural compounds for determination of antifungal activity had been developed with adaptations. The most used are bioautography and agar diffusion with a complex and no defined media. In this study, different methods for determination of antifungal activity of natural products are discussed and the use of M27-A2 microdilution test from CLSI (Clinical and Laboratory Standards Institute, 2002), as general standard methodology for testing plant extracts activity is recommended.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Natural products; Antifungal activity; Candida sp; Cryptococcus sp.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300001
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Screening methods to determine antibacterial activity of natural products BJM
Valgas,Cleidson; Souza,Simone Machado de; Smânia,Elza F A; Smânia Jr.,Artur.
The emergence of new infectious diseases, the resurgence of several infections that appeared to have been controlled and the increase in bacterial resistance have created the necessity for studies directed towards the development of new antimicrobials. Considering the failure to acquire new molecules with antimicrobial properties from microorganisms, the optimization for screening methods used for the identification of antimicrobials from other natural sources is of great importance. The objective of this study was to evaluate technical variants used in screening methods to determine antibacterial activity of natural products. Thus, a varied range of natural products of plant, fungi and lichen origin were tested against two bacterial species,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Agar diffusion; Antimicrobial activity; Bioautographic methods; Minimum inhibitory concentration; Minimum bactericidal concentration; Natural products.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000200034
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Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field BJPS
Paiva,Lívia Brenelli de; Goldbeck,Rosana; Santos,Wanderley Dantas dos; Squina,Fabio Marcio.
Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ferulic acid/properties; Ferulic acid/antioxidant activity; Ferulic acid/dietary sources; Ferulic acid/therapeutic effects; Natural products; Pharmacognosy.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300002
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Sustainability, natural and organic cosmetics: consumer, products, efficacy, toxicological and regulatory considerations BJPS
Fonseca-Santos,Bruno; Corrêa,Marcos Antonio; Chorilli,Marlus.
The interest in sustainable products has increased along the years, since the choice of products, packaging and production processes have a great impact on the environment. These products are classified by regulatory agencies in different categories, aggregating advantages to the product and increasing the demand by consumers. However, there is no harmonization in guidelines of these certifying agencies and each cosmetic industry formulates their product and packaging in a more rational way, which causes less damage to the environment. Many cosmetic products have in their formulation natural products that perform a specific biological function, but these products should be evaluated on efficacy and toxicological aspects. The aim of this article is to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Organic cosmetics; Natural cosmetics; Natural products; Sustainability; Cosmetics; Cosmetics.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100017
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Strategies towards expansion of chemical space of natural product-based compounds to enable drug discovery BJPS
Silva,Daniel Gedder; Emery,Flavio da Silva.
Natural products (NPs) are an excellent source of biologically active molecules that provide many biologically biased features that enable innovative designing of synthetic compounds. NPs are characterized by high content of sp3-hybridized carbon atoms; oxygen; spiro, bridged, and linked systems; and stereogenic centers, with high structural diversity. To date, several approaches have been implemented for mapping and navigating into the chemical space of NPs to explore the different aspects of chemical space. The approaches providing novel opportunities to synthesize NP-inspired compound libraries involve NP-based fragments and ring distortion strategies. These methodologies allow access to areas of chemical space that are less explored, and consequently...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemical space; Natural products; Ring distortion; Fragment-based drug discovery; Diversity-oriented synthesis; Chemical degradation.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700403
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Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers BJPS
Reinas,Alexandre Espada; Hoscheid,Jaqueline; Outuki,Priscila Miyuki; Cardoso,Mara Lane Carvalho.
An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescensBenth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pterodon pubescensBenth./pharmacognosy; Sucupira; Microcapsules/preparation; Vouacapans; Alginate; Chitosan; Coacervation method; Natural polymers; Natural products.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400919
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Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers BJPS
Durairaj,Brindha; Dorai,Arthi.
Nelumbo nucifera Gaertn (Nelumbonaceae) a plant used in Ayurvedic medicine (common name: lotus), is a perennial, large and rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white and pink Nelumbo nucifera flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of Nelumbo nucifera flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of both types of flowers was studied using platelet-rich plasma in different concentrations (100-500µg/ml). Both white and pink Nelumbo nucifera flower extracts showed dose-dependent effective antiplatelet activity with maximum activity at...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nelumbo nucifera Gaertn/phytochemical constituents; Nelumbo nucifera Gaertn/pharmacognosy; Nelumbo nucifera Gaertn/Antiplatelet activity; Ayurvedic medicine; Natural products; Aspirin.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300023
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Composition and Bioactive Properties of Yerba Mate (llex paraguariensis A. St.-Hil.): A Review Chilean J. Agric. Res.
Burris,Kellie P; Harte,Federico M; Michael Davidson,P; Neal Stewart Jr,C; Zivanovic,Svetlana.
Yerba Mate is a popular tea beverage produced and consumed in the South American countries of Argentina, Brazil, Chile, Paraguay, and Uruguay, and is processed from the leaves and stems of Ilex paraguariensis A. St.-Hil., a perennial shrub from the Aquifoliaceae family. Production occurs in six stages: harvesting older leaves and small stems, roasting by direct fire, drying under hot air, milling to specified size, aging to acquire optimal sensory attributes, and final packaging. While grown and consumed for centuries in South America, its popularity is increasing in the United States because of demand by consumers for healthier, more natural foods, its filling a niche for a different type of tea beverage, and for Yerba Mate's potential health benefits -...
Tipo: Journal article Palavras-chave: Antioxidant; Antimicrobials; Natural products; Yerba mate; Tea.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392012000200016
Registros recuperados: 48
Primeira ... 123 ... Última
 

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