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The Role of Antioxidants in Cerebellar Development: A Review of Literature International Journal of Morphology
Imosemi,I. O.
Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reacting oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction, and that the embryonic processes regulating the balance of ROS formation, oxidative DNA damage and repair, and ROS-mediated signal transduction may be important determinants of teratological risk. ROS can oxidize molecular targets such as DNA, protein, lipid in a process called oxidative stress resulting in cellular dysfunction and in utero death or teratogenicity. This review, consisting of literature search of journals and chapters in books aims at highlighting the importance of the cerebellum in controlling various motor activities in the body, as well...
Tipo: Journal article Palavras-chave: Cerebellar development; Reacting oxygen species; Oxidative stress; Antioxidants.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000100034
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Cytotoxic activity of Androctonus australis hector venom and its toxic fractions on human lung cancer cell line J. Venom. Anim. Toxins incl. Trop. Dis.
Béchohra,Louisa; Laraba-Djebari,Fatima; Hammoudi-Triki,Djelila.
Abstract Background: Several studies have showed that animal venoms are a source of bioactive compounds that may inhibit the growth of cancer cells, which makes them useful agents for therapeutic applications. Recently, it was established that venom toxins from scorpions induced cytotoxic, antiproliferative and apoptogenic effects on cancer cells. Therefore, the present study aims to investigate the cytotoxic activity of Androctonus australis hector (Aah) scorpion venom and its toxic fractions (FtoxG-50 and F3) on NCI-H358 human lung cancer cells. Methods: The cytotoxic and antiproliferative activities were estimated using MTT assay, lactate dehydrogenase release and clonogenic assays. Apoptosis was evaluated by Hoechst 33258 staining, DNA fragmentation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aah venom; Cytotoxicity; F3 fraction; Apoptosis; Lung cancer cells; Oxidative stress.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100322
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Rattlesnake Crotalus molossus nigrescens venom induces oxidative stress on human erythrocytes J. Venom. Anim. Toxins incl. Trop. Dis.
Meléndez-Martínez,David; Muñoz,Juan Manuel; Barraza-Garza,Guillermo; Cruz-Peréz,Martha Sandra; Gatica-Colima,Ana; Alvarez-Parrilla,Emilio; Plenge-Tellechea,Luis Fernando.
Abstract Background Globally, snake envenomation is a well-known cause of death and morbidity. In many cases of snakebite, myonecrosis, dermonecrosis, hemorrhage and neurotoxicity are present. Some of these symptoms may be provoked by the envenomation itself, but others are secondary effects of the produced oxidative stress that enhances the damage produced by the venom toxins. The only oxidative stress effect known in blood is the change in oxidation number of Fe (from ferrous to ferric) in hemoglobin, generating methemoglobin but not in other macromolecules. Currently, the effects of the overproduction of methemoglobin derived from snake venom are not extensively recorded. Therefore, the present study aims to describe the oxidative stress induced by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Attenuated total reflectance-Fourier transform infrared spectroscopy; Crotalus molossus nigrescens; Venom; Snake venom; Methemoglobin; Oxidative stress; Oxyhemoglobin.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100311
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Hepatotoxicity and oxidative stress induced byNaja haje crude venom J. Venom. Anim. Toxins incl. Trop. Dis.
Al-Quraishy,Saleh; Dkhil,Mahamed A; Moneim,Ahmed Esmat Abdel.
Background Snake venoms are synthesized and stored in venom glands. Most venoms are complex mixtures of several proteins, peptides, enzymes, toxins and non-protein components. In the present study, we investigated the oxidative stress and apoptosis in rat liver cells provoked by Naja haje crude injection (LD50) after four hours.Methods Wistar rats were randomly divided into two groups, the control group was intraperitoneally injected with saline solution while LD50-dose envenomed group was intraperitoneally injected with venom at a dose of 0.025 μg/kg of body weight. Animals were killed four hours after the injection. Lipid peroxidation, nitric oxide and glutathione levels were measured as oxidative markers in serum and liver homogenate. In addition, liver...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Naja haje venom; Hepatotoxicity; Oxidative stress; Apoptosis; Rats.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200314
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Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction J. Venom. Anim. Toxins incl. Trop. Dis.
Abdel-Rahman,Mohamed A; Abdel-Nabi,Ismail M; El-Naggar,Mohamed S; Abbas,Osama A; Strong,Peter N.
Background It is estimated that venoms of marine cone snails (genus Conus) contain more than 100,000 different small peptides with a wide range of pharmacological and biological actions. Some of these peptides were developed into potential therapeutic agents and as molecular tools to understand biological functions of nervous and cardiovascular systems. In this study we examined the cytotoxic and anticancer properties of the marine vermivorous cone snail Conus vexillum (collected from Hurgada and Sharm El-Shaikh, Red Sea, Egypt) and suggest the possible mechanisms involved. The in vitro cytotoxic effects of Conus venom were assessed against Ehrlich’s ascites carcinoma (EAC) cells. Results Conus venom treatment resulted in concentration-dependent...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Conus vexillum venom; Ehrlich’s cells; Oxidative stress; Cancer; Egypt.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100307
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Antiproliferative activity of marine stingray Dasyatis sephenvenom on human cervical carcinoma cell line J. Venom. Anim. Toxins incl. Trop. Dis.
Rajeshkumar,RK; Vennila,R; Karthikeyan,S; Prasad,N Rajendra; Arumugam,M; Velpandian,T; Balasubramaniam,T.
AbstractBackgroundVenoms comprise mixtures of numerous bioactive compounds that have a wide range of pharmacologic actions. Toxins from venomous animals have attracted the attention of researchers because of their affinity for primary sites responsible for lethality and their efficacy at extremely low concentrations. The venoms of marine stingrays have not been extensively studied and limited data is available on them. The present study aims to evaluate the antiproliferative and biochemical properties of the venom obtained from a species of marine stingray (Dasyatis sephen) on human cervical cancer cell line HeLa.MethodsThe antiproliferative effect of D. sephen venom was determined by MTT assay, and the oxidative stress was determined by lipid peroxidation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Marine organisms; Membrane potential; Oxidative stress; ROS; Stingray; Venom.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100345
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Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat J. Venom. Anim. Toxins incl. Trop. Dis.
Saoudi,M; Abdelmouleh,A; Ellouze,F; Jamoussi,K; El Feki,A.
This study was undertaken to evaluate the effect of pufferfish (Lagocephalus lagocephalus) meat poisoning on hepatic functions of Wistar rats. For this purpose, groups of rats (Lcr, Lcu+b and Lcu-b) received diet supplemented with 10% of raw or cooked meat, respectively, with or without cooking water of L. lagocephalus while groups Mcr and Mcu+b received diet supplemented with 10% of raw or cooked meat of Liza aurata, which were used as a negative control. In Lcu+b group, ALT, AST and ALP rates (hepatic enzyme markers) decreased after two months of treatment, indicating liver damage. We also observed an increase of 54 and 65% of thiobarbituric acid reactive substances (TBARS) in their livers respectively 48 hours and two months after treatment compared to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatotoxicity; Lagocephalus lagocephalus; Oxidative stress; Tetrodotoxin.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300006
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The essential oil from Lippia alba induces biochemical stress in the silver catfish (Rhamdia quelen) after transportation Neotropical Ichthyology
Salbego,Joseânia; Becker,Alexssandro G.; Gonçalves,Jamile F.; Menezes,Charlene C.; Heldwein,Clarissa G.; Spanevello,Rosélia M.; Loro,Vania L.; Schetinger,Maria Rosa C.; Morsch,Vera M.; Heinzmann,Berta M.; Baldisserotto,Bernardo.
This study investigated the effects of the essential oil (EO) from Lippia alba on biochemical parameters related to oxidative stress in the brain and liver of silver catfish (Rhamdia quelen) after six hours of transport. Fish were transported in plastic bags and divided into three treatments groups: control, 30 µL L- 1 EO from L.alba and 40 µL L-1 EO from L.alba. Prior to transport, the fish were treated with the EO from L. alba (200 µL L -1 for three minutes), except for the control group. Fish transported in bags containing the EO did not have any alterations in acetylcholinesterase, ecto -nucleoside triphosphate diphosphohydrolase and 5'nucleotidase activity in the brain or superoxide dismutase activity in the liver. The hepatic catalase (CAT),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthetics; Antioxidant defenses; Biochemical parameters; Fish transport; Oxidative stress.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252014000400811
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Probucol dramatically enhances dihydroartemisinin effect in murine malaria OAK
Kume, Aiko; Dang Trinh Minh Anh; Shichiri, Mototada; Ishida, Noriko; Suzuki, Hiroshi.
Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are spreading, with slow-cleaning parasites being reported in patients treated with ACT. It means that more parasites are exposed to the partner drug alone and the risk of developing resistant parasites against the partner drug is increasing. Therefore, the development of a new method to enhance the effect of artemisinin is required. In this study, the potential effect of probucol as a combination drug of dihydroartemisinin (DHA), an artemisinin derivative, was examined. Methods: C57BL/6 J mice infected with Plasmodium yoelii XL-17 were...
Palavras-chave: C57BL/6 J mice; Dihydroartemisinin; Malaria; Oxidative stress; Probucol; Plasmodium yoelii XL-17; Vitamin E.
Ano: 2016 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4436
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Growth, antioxidant system, and immunological status of shrimp in bioflocs and clear water culture systems PAB
Souza,Diego Moreira de; Kutter,Mateus Tavares; Furtado,Plinio Schmidt; Romano,Luis Alberto; Wasielesky Junior,Wilson; Monserrat,José María; Garcia,Luciano.
Abstract: The objective of this work was to evaluate the effect of the traditional culture system in clear water and of the one in microbial flocs on the antioxidant and immunological status of Litopenaeus vannamei shrimp. Samples (gill, hemolymph, and hepatopancreas) were collected on days 15, 30, and 60 of the experimental period. The following immunological parameters were analyzed at each evaluation time: granular and hyaline hemocytes, total protein, and apoptosis. Assays on glutamate-cysteine ligase (GCL) activity and on the concentrations of reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) were also performed. The evaluated immunological parameters did not differ significantly between treatments. Shrimp reared in clear...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Litopenaeus vannamei; BFT; Oxidative stress; TBARS.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2019000101100
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Effects of high arsenic and fluoride soil concentrations on soybean plants Phyton
Bustingorri,C; Balestrasse,K; Lavado,RS.
Arsenic (As) and Fluoride (F) are present in many soils, affecting crops and posing risks in the food chain. We performed pot experiments on spiked soils enriched in these elements either individually or simultaneously, over a wide range of concentrations. Soybean biomass production, grain yield, As and F accumulation and distribution within the plant, and the antioxidant response to these stresses were analyzed. Arsenic was more toxic than F. At As levels >35 mg/kg and F levels >375 mg/kg, yield loss reached 60% and 30%, respectively. At the highest dose of As plants died within 2 weeks, whereas F showed no lethality. When they were applied simultaneously, detrimental effects were more important. As and F in plants increased in all soybean organs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Soil contamination; Toxic elements in crops; Grain contamination; Oxidative stress; Soybean.
Ano: 2015 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572015000200020
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Physiological responses of Allium cepa var. agrogarum L. plants to Cadmium stress Phyton
Wang,QL; Liu,DH; Yue,JY.
This study aimed to determine the effects of different Cd concentrations (0, 1, 10, 100, and 300 µM CdCl2) on Allium plantlets. To achieve this goal, we examined the (1) dynamics of Cd2+ fux in the rhizosphere, (2) partitioning of Cd between roots and leaves, (3) formation of reactive oxygen species (ROS), (4) levels of H2O2 and chlorophyll, and (5) translocation of several macro- and micronutrients. A strong net Cd2+ influx was observed in the root apex after exposure to 100 µM Cd for 24 h. Exposure to either 1 or 10 µM Cd for 96 h presented no evident influence on root growth. However, treatments with 100 to 300 µM Cd for 72 h significantly inhibited root growth. ROS levels increased in roots and leaves with increasing Cd concentrations. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cadmium (Cd) toxicity; Net cadmium flux; ICP; Oxidative stress; Photosynthesis.
Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572016000200015
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Interference of Volunteer Corn on Stress Metabolism and Yield of Dry Beans Planta Daninha
PIASECKI,C.; RIZZARDI,M.A.; SCHONS,J.; CAVERZAN,A.; OLIVEIRA,C..
ABSTRACT: Dry bean cultivation after corn favors the occurrence of volunteer corn plants which interfere with the crop and cause yield losses of dry bean. Yield losses resulting from interferences caused by corn may be related to oxidative stress, which, in turn, is caused by the higher production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2). This work aimed to quantify H2O2 contents, and the activity of superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX) in dry beans under interference with densities of volunteer corn F2 originated from individual plants and clumps (seven corn plants emerged at the same point). Two experiments were carried out in a randomized blocks design with three replicates in Passo Fundo -...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phaseolus vulgaris; Zea mays; Clumps; Oxidative stress.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582018000100310
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Morphological and Biochemical Alterations of Paddy Rice in Response to Stress Caused by Herbicides and Total Plant Submersion Planta Daninha
MARCHEZAN,M.G.; AVILA,L.A.; AGOSTINETTO,D.; SCHAEDLER,C.E.; LANGARO,A.C.; OLIVEIRA,C.; ZIMMER,M.; SCHREIBER,F..
ABSTRACT Herbicide selectivity in paddy rice varies in several aspects, among which are the environmental conditions. The aim of the study was to evaluate the effect of herbicide application and total plant submersion on morphological and biochemical changes in paddy rice. Total chlorophyll and carotenoids, catalase activity, ascorbate peroxidase and superoxide dismutase, total phenolic content, lipid peroxidation and hydrogen peroxide levels were assessed. Leaf samples were collected 24 hours and 7 days after the application of water regimes. The results observed in the first experiment show that cultivars Puitá INTA CL, IRGA 417 and IRGA 422 CL are more tolerant to total submersion. The most sensitive cultivars are IRGA 424, BRS Querência, EPAGRI 108 and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxidative stress; Hypoxia; Oryza sativa; Herbicide selectivity.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582017000100201
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Biochemical and Physiological Changes in Rice Plants Due to the Application of Herbicides1 Planta Daninha
LANGARO,A.C.; AGOSTINETTO,D.; OLIVEIRA,C.; SILVA,J.D.G.; BRUNO,M.S..
ABSTRACT The application of herbicides, even if selective, can cause biochemical and physiological changes, resulting in oxidative stress. This stress comes from the accumulation of reactive oxygen species produced due to exposure to the herbicide. However, plants have developed defense strategies, which can be enzymatic or non-enzymatic. The objective of this study was to evaluate the morphological and metabolic changes such as photosynthetic parameters, oxidative damage and antioxidant enzyme activity of rice plants after applying herbicides. For this, a study was conducted in a greenhouse and laboratory and the treatments consisted of application of imazapic + imazapyr, quinclorac, bentazon, cyhalofop-butyl, penoxsulan, bispyribac-sodium and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oryza sativa; Oxidative stress; Lipid peroxidation; Selectivity.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582016000200277
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Changes in the Metabolism of Soybean Plants Submitted to Herbicide Application in Different Weed Management Systems Planta Daninha
FRAGA,D.S.; AGOSTINETTO,D.; RUCHEL,Q.; LANGARO,A. C.; OLIVEIRA,C..
ABSTRACT: Technologies that advocate the use of herbicide-resistant crops are alternatives to weed control, but they may cause oxidative stress and change secondary metabolism of plants. Therefore, this study aimed to evaluate changes in the secondary metabolism of soybean plants which contained Cultivance® (CV), sulfonylurea-tolerant soybean (STS) and Roundup Ready® (RR) technologies submitted to the application of the mixture of herbicides imazapyr and imazapic in “plant-apply” and “apply-plant” management systems. Two field experiments, in which soybean cultivars were submitted to increasing doses of the mixture of herbicides imazapyr and imazapic, were performed. Aerial parts of plants were collected 10 days after crop emergence and stored at -83oC,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycine max; Oxidative stress; Chemical control.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582020000100243
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Morphological and physiological alterations induced by lactofen in soybean leaves are reduced with nitric oxide Planta Daninha
Ferreira,L.C; Cataneo,A.C; Remaeh,L.M.R; Búfalo,J; Scavroni,J; Andréo-Souza,Y; Cechin,I; Soares,B.J.A.
Lactofen is a diphenylether herbicide recommended to control broad-leaved weeds in soybean (Glycine max) fields and its mechanism of action is the inhibition of protoporphyrinogen-IX oxidase (Protox), which acts in the chlorophyll biosynthesis. This inhibition results in an accumulation of protoporphyrin-IX, which leads to the production of reactive oxygen species (ROS) that cause oxidative stress. Consequently, spots, wrinkling and leaf burn may occur, resulting in a transitory crop growth interruption. However, nitric oxide (NO) acts as an antioxidant in direct ROS scavenging. Thus, the aim of this work was to verify, through phytometric and biochemical evaluations, the protective effect of NO in soybean plants treated with the herbicide lactofen....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycine max; Oxidative stress; Plant growth; Soluble sugars.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582011000400014
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Physiological and Molecular Responses in Rice, Weedy Rice and Barnyardgrass Exposed to Supra-Optimal Temperatures Planta Daninha
OLIVEIRA,C.; AGOSTINETTO,D.; LANGARO,A.C.; GARCIA,J.R.; LAMEGO,F.P..
ABSTRACT: The global temperature to rise 0.3 to 4.8 oC to century. Supra-optimal temperatures can affect plants at different organizational levels, causing morphological, physiological, biochemical and gene expression alterations. Rice, weedy rice, and barnyardgrass may to response differently when subjected to supra-optimal temperatures. Thus, the aimed at determining the physiological response and expression of the genes APX2, HSP24.15 e HSP71.10 in rice, weedy rice, and barnyardgrass when in to supra-optimal temperatures. A greenhouse experiment was conducted in randomized complete desing with four repetitions, with a factorial combination of temperature x plantas, where: factor A consisted of two temperatures (25 oC and 40 oC); and factor B of three...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oryza sativa; Echinochloa spp.; Photosynthesis; Oxidative stress; Gene expression.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100239
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CHANGE IN PHYSIOLOGICAL FEATURES IN RYEGRASS BIOTYPES IN COMPETITION WITH SOYBEAN DUE RESISTANCE TO GLYPHOSATE Planta Daninha
AGOSTINETTO,D.; OLIVEIRA,C.; LANGARO,A.C.; NOHATTO,M.A.; MANICA-BERTO,R..
ABSTRACT Herbicide resistance can cause biochemical, physiological, morphological and phenological changes in weeds, altering their competitive ability against crops. The aim of the study was to assess physiological changes and cellular damage in susceptible and resistant biotypes of ryegrass and soybeans under competition. Three experiments were conducted in a greenhouse using a completely randomized design with four replications performed in a replacement series. The ratios of soybean and to susceptible (experiment 1) and resistant ryegrass (experiment 2) and of susceptible to resistant (experiment 3) ryegrass were 100:0, 75:25, 50:50, 25:75 and 0:100. Forty days after the emergence of the soybean crop and 60 days after the emergence of the ryegrass...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxidative stress; Antioxidant enzymes; Adaptability of herbicide resistant plants.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582016000300517
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Responses of Plants to Pesticide Toxicity: an Overview Planta Daninha
SHARMA,A.; KUMAR,V.; THUKRAL,A.K.; BHARDWAJ,R..
ABSTRACT: Pesticides are applied all over the world to protect plants from pests. However, their application also causes toxicity to plants, which negatively affects the growth and development of plants. Pesticide toxicity results in reduction of chlorophyll and protein contents, accompanied by decreased photosynthetic efficiency of plants. Pesticide stress also generates reactive oxygen species which causes oxidative stress to plants. To attenuate the negative effects of oxidative stress, the antioxidative defense system of plants gets activated, and it includes enzymatic antioxidants as well as non-enzymatic antioxidants. The present review gives an overview of various physiological responses of plants under pesticide toxicity in tabulated form.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Physiological responses; Antioxidative defense system; Oxidative stress.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100303
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