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| Registros recuperados: 49 | |
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| Evora,P.R.B.; Ekin,S.; Pearson,P.J.; Schaff,H.V.. |
| Early systemic arterial hypotension is a common clinical feature of Pseudomonas septicemia. To determine if Pseudomonas aeruginosa endotoxin induces the release of endothelium-derived nitric oxide (EDNO), an endogenous nitrovasodilator, segments of canine femoral, renal, hepatic, superior mesenteric, and left circumflex coronary arteries were suspended in organ chambers (physiological salt solution, 95% O2/5% CO2, pH 7.4, 37oC) to measure isometric force. In arterial segments contracted with 2 µM prostaglandin F2<FONT FACE="Symbol">a</font>, Pseudomonas endotoxin (lipopolysaccharide (LPS) serotype 10(Habs) from Pseudomonas aeruginosa (0.05 to 0.50 mg/ml)) induced concentration-dependent relaxation of segments with endothelium (P<0.05)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endothelium-derived relaxing factor; EDRF; Nitric oxide; Hypotension; Sepsis. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000014 |
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| Silva,S.C.; Baggio-Zappia,G.L.; Brunialti,M.K.C.; Assunçao,M.S.C.; Azevedo,L.C.P.; Machado,F.R.; Salomao,R.. |
| Recognition of pathogens is performed by specific receptors in cells of the innate immune system, which may undergo modulation during the continuum of clinical manifestations of sepsis. Monocytes and neutrophils play a key role in host defense by sensing and destroying microorganisms. This study aimed to evaluate the expression of CD14 receptors on monocytes; CD66b and CXCR2 receptors on neutrophils; and TLR2, TLR4, TLR5, TLR9, and CD11b receptors on both cell types of septic patients. Seventy-seven septic patients (SP) and 40 healthy volunteers (HV) were included in the study, and blood samples were collected on day zero (D0) and after 7 days of therapy (D7). Evaluation of the cellular receptors was carried out by flow cytometry. Expression of CD14 on... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Toll-like receptors; TLR5; TLR9; CXCR2. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500384 |
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| Oliveira-Junior,I.S.; Brunialti,M.K.C.; Koh,I.H.J.; Junqueira,V.B.C.; Salomão,R.. |
| Experimental models of sepsis-induced pulmonary alterations are important for the study of pathogenesis and for potential intervention therapies. The objective of the present study was to characterize lung dysfunction (low PaO2 and high PaCO2, and increased cellular infiltration, protein extravasation, and malondialdehyde (MDA) production assessed in bronchoalveolar lavage) in a sepsis model consisting of intraperitoneal (ip) injection of Escherichia coli and the protective effects of pentoxifylline (PTX). Male Wistar rats (weighing between 270 and 350 g) were injected ip with 10(7) or 10(9) CFU/100 g body weight or saline and samples were collected 2, 6, 12, and 24 h later (N = 5 each group). PaO2, PaCO2 and pH were measured in blood, and cellular influx,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute lung injury; Sepsis; Inflammatory mediators; Pentoxifylline; Neutrophils. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100009 |
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| Bacci,M.R.; Leme,R.C.P.; Zing,N.P.C.; Murad,N.; Adami,F.; Hinnig,P.F.; Feder,D.; Chagas,A.C.P.; Fonseca,F.L.A.. |
| Community-acquired pneumonia (CAP) is amongst the leading causes of death worldwide. As inflammatory markers, cytokines can predict outcomes, if interpreted together with clinical data and scoring systems such as CURB-65, CRB, and Acute Physiology and Chronic Health Evaluation II (APACHE II). The aim of this study was to determine the impact of inflammatory biomarkers on the early mortality of hospitalized CAP patients. Twenty-seven CAP patients needing hospitalization were enrolled for the study and samples of interleukin-1 (IL-1) and interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and homocystein were collected at the time of admission (day 1) as well as on the seventh day of the treatment. There was a significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Community acquired pneumonia; Interleukin-6; Tumor necrosis factor α; Sepsis. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000500427 |
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| Loureiro,Marcio M.; Moraes,Bianca A. de; Quadra,Maria R.R.; Pinheiro,Glenda S.; Asensi,Marise D.. |
| The aims of this study were to determine the frequency and antimicrobial resistance patterns of microorganisms associated with sepsis cases in a public maternity hospital, and to analyze the main demographic data relating to these infected neonates over a two year period. We analyzed 255 positive blood cultures and the medical records of newborns admitted to the neonatal intensive care unit of the Hospital Maternidade Alexander Fleming II, Rio de Janeiro city, Brazil, from July 1997 to July 1999. Identification and antibiograms of the isolated strains were performed according to routine laboratory procedures. Demographics and microbiological data were analyzed using the Epi-Info program. The mean age of the newborns was 13.1 days, with an average of 1.2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Epidemiology; Newborns; Hospital infection; Sepsis; Antimicrobial resistance. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000100015 |
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| Lee,Bong-Seon; Yang,Sumin; Lee,Changhun; Ku,Sae-Kwang; Bae,Jong-Sup. |
| This study was initiated to determine whether 2 structurally related flavonoids found in Cyclopia subternata-vicenin-2 (VCN) and scolymoside (SCL)-could modulate renal functional damage in a mouse model of sepsis, and to elucidate the relevant underlying mechanisms. The potential of VCN and SCL treatment to reduce renal damage induced by cecal ligation and puncture (CLP) surgery in mice was measured via assessment of serum creatinine, blood urea nitrogen (BUN), lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, and superoxide dismutase activity. Treatment with either VCN or SCL resulted in elevated plasma levels of BUN and creatinine, and of protein in the urine of mice with CLP-induced renal damage. Moreover, both... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vicenin-2; Scolymoside; Sepsis; Antioxidant; Renal injury; Renal toxicity. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100578 |
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| Registros recuperados: 49 | |
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