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Registros recuperados: 142
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Pharmacobotanic characterization of young stems and stem barks of Rauvolfia sellowii Müll. Arg., Apocynaceae BJPS
Baratto,Leopoldo Clemente; Duarte,Márcia do Rocio; Santos,Cid Aimbiré de Moraes.
Rauvolfia sellowii Müll. Arg. (Apocynaceae), a Brazilian native tree rich in indole alkaloids, is known as "pau-pra-tudo" and popularly used as hypocholesterolemic, hypoglycemic and antihypertensive. The aim of this work was to study the anatomy of the young stems and stem barks of this medicinal plant, in order to contribute to the identification of the species as a drug. The plant material was fixed and prepared according to standard microtechniques. The young stems have remaining epidermis, but a suberified peridermis is evident. The phellogen is located in the cortical region, forming suber externally. Underneath the phellogen, lies the phelloderm and collenchymatic region. In the cortex, there are numerous laticifers and some fibers. There is an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rauvolfia sellowii/pharmacognosy; Apocynaceae/pharmacognosy; Medicinal plants; Vegetal anatomy; Internal phloem; Laticiferous ducts; Calcium oxalate crystals.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300020
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Safety assessment and behavioral effects of Solanum guaraniticum leaf extract in rats BJPS
Bonfanti,Gabriela; Bitencourt,Paula Eliete Rodrigues; Bona,Karine Santos De; Peroza,Luis Ricardo; Cargnelutti,Lariane Oliveira; Borges,Raphaela Maleski; Pigatto,Aline Grohe Schirmer; Fachinetto,Roselei; Boligon,Aline Augusti; Athayde,Margareth Linde; Gonçalves,Thissiane de Lima; Moretto,Maria Beatriz.
ABSTRACT Solanum guaraniticum is a medicinal plant traditionally used to treat gastric and liver diseases. However, there is no documented evidence corroborating its safety. The present study evaluated the potential toxicity of S. guaraniticum leaf extract after acute administration in rats. Single doses of the extract (1.250, 2.500, and 5.000 mg/kg) were administered by gavage, and the rats were then monitored for 48 h and/or 14 days. Mortality, acute signs of toxicity, and general activity in the open field test were assessed as well as hematological and biochemical parameters, enzymatic activity (δ-aminolevulinate dehydratase and acetylcholinesterase), and oxidative stress parameters (lipid peroxidation level, non-protein thiol content, tissue catalase...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Solanum guaraniticum/leaf extract/toxicity; Solanum guaraniticum/phytochemistry; Medicinal plants; Solanaceae.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100006
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Protective effect of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats BJPS
Song-Tao,Ma; Dong-lian,Liu; Jing-jing,Deng; Yan-juan,Peng.
Mulberry leaves (Morus alba L.) are a traditional Chinese medicine for blood serum glucose reduction. This study evaluated the protective effects of mulberry flavonoids on sciatic nerve in alloxan-induced diabetic rats. In this study, 80 Sprague-Dawley rats were divided into five groups: A (control), B (diabetic treated with saline), C-D (diabetic treated with 0.3, 0.1 g/kg mulberry flavonoids once a day for 8 weeks) and E (diabetic treated with 0.3 mg/kg methycobal). The diabetic condition was induced by intraperitoneal injection of 200 mg/kg alloxan dissolved in saline. At the end of the experimental period, blood, and tissue samples were obtained for biochemical and histopathological investigation. Treatment with 0.3 g/kg mulberry flavonoids...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Morus albaL./pharmacognosy; Mulberry flavonoids/protective effects/experimental study; Diabetic neuropathy/experimental study; Medicinal plants; Diabetics/treatment/experimental study.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400765
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Ethnopharmacological survey: a selection strategy to identify medicinal plants for a local phytotherapy program BJPS
Pereira,Flávia Liparini; Fernandes,José Martins; Leite,João Paulo Viana.
Ethnopharmacological studies are important for documenting and protecting cultural and traditional knowledge associated with the medical use of biodiversity. In this paper, we present a survey on medicinal plants used by locals in a community of Nova Viçosa, Viçosa, MG, Brazil, as a strategy to select medicinal plants for a phytotherapy-based local healthcare program. Eleven knowledgeable local informants were chosen by snowball sampling and interviewed about the use of medicinal plants. Plant samples were collected, herborised and then identified using traditional techniques and specialised literature. We sampled 107 medicinal plant species belonging to 86 genera and 39 families, predominantly Asteraceae with 16 species. Costus spicatus (Jacq.) Sw, M....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ethnopharmacology; Medicinal plants; Phytotherapy.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200014
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In vitro antifungal activity and phytochemical characterization of Eugenia uniflora, Libidibia ferrea and Psidium guajava BJPS
Ferreira,Magda Rhayanny Assunção; Santiago,Rosilene Rodrigues; Silva-Rocha,Walicyranison Plínio; Souza,Luanda Barbara Ferreira Canário de; Faria,Maria Graciela Icher; Mello,João Carlos Palazzo de; Langassner,Silvana Maria Zucolotto; Chaves,Guilherme Maranhão; Milan,Eveline Pipolo; Svidzinski,Terezinha Inez Estivalet; Soares,Luiz Alberto Lira.
The aim of this study was evaluate the in vitro antifungal activity of crude extracts from Eugenia uniflora, Libidibia ferrea and Psidium guajava. The extracts were obtained by turbo-extraction using water (AQ) or acetone-water (AC-W) (7:3, v/v) as solvents and lyophilized to obtain the crude extracts (CE). The CE were characterized by UV-Vis, TLC and HPLC. The activity of CEs was investigated against clinical isolates of Candida spp. and the Minimum Inhibitory Concentration (MIC), MIC50 and MIC90 were determinated. The analysis by TLC showed that all CEs presented polyphenols (flavonoids and tannins). The CEs from E. uniflora showed higher amount of polyphenols (30.35 ± 2.15%, AC-W) and the HPLC analysis revealed the tannins in all extracts. The CEs of E....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Herbal extracts; Polyphenols; Candida isolates; Oral candidiasis.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100608
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Evaluation of anti-estrogenic or estrogenic activities of aqueous root extracts of Gunnera manicata L. BJPS
Mariotti,Kristiane de Cássia; Schmitt,Gabriela Cristina; Barreto,Fabiano; Fortunato,Rodrigo E.; Singer,Rodrigo B.; Dallegrave,Eliane; Leal,Mirna Bainy; Limberger,Renata Pereira.
Gunnera perpensa (Gunneraceae) is an African plant widely used in traditional medicine. This species is known for its activity involving the female reproductive system, such as inducing or increasing labor, treating female infertility, expelling the placenta and/or preventing post-partum hemorrhage. These properties are probably due to (z)-venusol, a majoritary compound, and its action in conjunction with substances in the whole extract and other natural products. In southern Brazil, a native species Gunnera manicata L. that also belongs to Gunneraceae can be found. In spite of the traditional use of G. perpensa, there is no pharmacological and phytochemical information regarding the South American Gunnera species. Therefore, the aim of this study was to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gunnera manicata L./pharmacognosy; Gunneraceae/pharmacognosy; Medicinal plants; Uterotrophic assay/experimental study.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300018
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Pharmacological activity of the hydroalcoholic extract from Hovenia dulcis thunberg fruit and the flavonoid dihydromyricetin during hypercholesterolemia induced in rats BJPS
Pinto,Juliana Tensol; Oliveira,Tânia Toledo de; Alvarenga,Luana Farah; Barbosa,Adriano Simões; Pizziolo,Virgínia Ramos; Costa,Marcelo Rocha da.
Cerebrovascular accidents and coronary artery disease are the leading causes of cardiovascular mortalities in Brazil and high levels of LDL cholesterol are one of the main risk factors. In this context, several plant extracts and natural substances have shown promise as cholesterol-lowering. The objective of this study was to evaluate the potential of the hydroalcoholic extract of the fruit of H. dulcisand of dihydromyricetin in cholesterol reduction in hypercholesterolemic rats. Forty-two Wistar male rats were distributed into seven groups of six animals that received diets supplemented with 1% cholesterol and 0.3% cholic acid, with the exception of the control group, which received conventional diets. Animals were treated with oral suspensions...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hovenia dulcis/pharmacognosy; Hovenia dulcis/hydroalcoholic extract/ cholesterol reduction; Hovenia dulcis/flavonoid dihydromyricetin/cholesterol reduction; Dihydromyricetin/cholesterol reduction; Hypercholesterolemia/experimental study; Medicinal plants.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400727
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In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei BJPS
Ammar,Ouahab.
ABSTRACT In-silico study was performed to find the pharmacodynamics, toxicity profiles and biological activities of three phytochemicals isolated from Limoniastrum feei (Plumbagenaceae). Online pharmacokinetic tools were used to estimate the potential of Quercetin, kaempferol-3-O-β-D-glucopyranoside (astragalin) and quercitin-7-O-β-D-glucopyranoside as specific drugs. Then the prediction of potential targets of these compounds were investigated using PharmMapper. Auto-Dock 4.0 software was used to investigate the different interactions of these compounds with the targets predicted earlier. The permeability of quercetin was found within the range stated by Lipinski ׳s rule of five. Hematopoietic prostaglandin (PG) D synthase (HPGDS), farnesyl diphosphate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Limoniastrum feei/pharmacokinetics; Limoniastrum feei/biological activity; Quercetin; Astragalin; Quercetin 7; Medicinal plants; Molecular docking.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300606
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Evaluation of the proliferative activity of methanol extracts from six medicinal plants in murine spleen cells BJPS
Zandonai,Rodrigo Hermes; Coelho,Fabiana; Ferreira,Juliana; Mendes,Ana Karla Bittencourt; Biavatti,Maique Weber; Niero,Rivaldo; Cechinel Filho,Valdir; Bueno,Ednéia Casagranda.
A number of natural compounds have been used as immunomodulatory agents, enabling the function of the immune system to be modified by stimulating or suppressing it. There has been increasing interest in the study of therapeutic action of plant extracts regarding their immunomodulatory activity. The aim of this study was to identify and evaluate the action of extracts of the medicinal plants Calophyllum brasiliense, Ipomoea pes-caprae, Matayba elaeagnoides, Maytenus robusta, Rubus imperialis and Vernonia scorpioides on the development of spleen cells from mice, using the in vitro cellular proliferation assay. The cells, obtained by mechanical rupture of mice spleen (5x10(4) cells/mL), were incubated with methanol extracts (10, 50, 100 and 200 µg/mL) and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal plants; Natural products/immunomodulatories; Immunomodulation; Calophyllum brasiliense/pharmacognosy; Ipomoea pes-caprae/pharmacognosy; Matayba elaeagnoides/pharmacognosy; Maytenus robusta/pharmacognosy; Rubus imperialis/pharmacognosy; Vernonia scorpioides/pharmacognosy.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200020
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Chromatographic analysis and antiproliferative potential of aqueous extracts of Punica granatum fruit peels using the Allium cepa test BJPS
Kuhn,Andrielle Wouters; Tedesco,Marília; Boligon,Aline Augusti; Athayde,Margareth Linde; Laughinghouse IV,Haywood Dail; Tedesco,Solange Bosio.
Punica granatum L., locally known as romanzeira, is native to Asia but found throughout Brazil. P. granatum is used for treating inflammatory, infectious and respiratory diseases. The aim of this study was to evaluate the chromatography and genotoxicity of an aqueous extract of P. granatum (pomegranate) fruit peel using the Allium cepa L. test. The experiment set-up entailed 7 treatments: T1-distilled water, T2-tea 5 g.L-1, T3-tea 10 g.L-1, T4-glyphosate at 9.6%, T5-glyphosate with subsequent recovery in distilled water, T6-glyphosate with subsequent recovery in tea 5 g.L-1 and T7-glyphosate with subsequent recovery in tea 10 g.L-1. The rootlets were collected and fixed in ethanol:acetic acid (3:1) for 24 hours, then stored in 70% ethanol under...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Punica granatum L./phytochemistry; Punica granatum L./genotoxicity Punica granatum L./chromatography analysis; Medicinal plants; Pomegranate.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100241
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Anti-inflammatory and toxicity studies of atranorin extracted from Cladina kalbii Ahti in rodents BJPS
Melo,Marcelia Garcez Dória de; Araújo,Adriano Antunes de Souza; Serafini,Mairim Russo; Carvalho,Larissa Feitosa; Bezerra,Marília Santos; Ramos,Cledison Santos; Bonjardim,Leonardo Rigoldi; Albuquerque-Júnior,Ricardo Luiz Cavalcanti; Lima,Julianeli Tolentino; Siqueira,Rosana Souza; Fortes,Vanessa Silveira; Fonseca,Maria José Vieira; Quintans-Júnior,Lucindo José.
Atranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was induced by injection of 500 µL of carrageenan into the peritoneal cavity of mice. In addition, we determined ATR cytotoxicity in L929 cells by MTT assay and acute (5 g/kg-single dose) and subchronic (50 mg/kg-30 days) toxicity tests in Wistar rats. The results showed that ATR (100 mg/kg and 200 mg/kg) exhibited significant anti-inflammatory activity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cladina kalbii/pharmacognosy; Atranorin/anti-inflamatory activity; Atranorin/toxicity; Medicinal plants.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400024
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Pharmaceutical properties of 'sucupira' (Pterodon spp.) BJPS
Hansen,Daiane; Haraguchi,Mitsue; Alonso,Antonio.
The plant of the genus Pterodon (Fabaceae, Leguminosae), commonly known as 'sucupira' or 'faveira', are disseminated throughout the central region of Brazil and has frequently been used in popular medicine for its anti-rheumatic, analgesic, and anti-inflammatory properties. In recent years, interest in these plants has increased considerably. The biological effects of different phytoextracts and pure metabolites have been investigated in several experimental models in vivo and in vitro. The literature describes flavonoids, triterpene and steroids, while one paper presented studies with proteins isolated from the genus. This review provides an overview of phytochemical and pharmacological research in Pterodon, showing the main chemical compounds studied to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sucupira; Pterodon/phytochemistry; Pterodon/pharmacognosy; Diterpenes/biological activity; Isoflavones/biological activity; Medicinal plants.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400002
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Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential BJPS
Pascoa,Henrique; Diniz,Danielle Guimarães Almeida; Florentino,Iziara Ferreira; Costa,Elson Alves; Bara,Maria Teresa Freitas.
This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone(r) R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1st, 7th, 15th, and 30th days after...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pterodon emarginatus; Pterodon emarginatus; Medicinal plants; Microemulsion; Phytomedicine; Pharmaceutical technology.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100117
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Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution BJPS
Sousa,Sandra Alves de; Pascoa,Henrique; Conceição,Edemilson Cardoso da; Alves,Suzana Ferreira; Diniz,Danielle Guimarães Almeida; Paula,José Realino de; Bara,Maria Teresa Freitas.
"Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three markers (caffeine, catechin and epicatechin), while 40% had only caffeine at tested dosage forms. In addition, after 30 minutes, only capsule A showed at least 80% of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Herbal medicines/quality control; Herbal medicines/dissolution behavior; Medicinal plants; Guaraná/pharmacognosy; Paullinia cupana/pharmacognosy.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200008
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Stability of Tilo® tablets formulation obtained from dry extract of Justice pectoralis Jacq. BJPS
Rodríguez-Chanfrau,Jorge E.; Núñez-Figueredo,Yanier; Fuste-Moreno,Viviana.
Justicia pectoralis Jacq., Acanthaceae, is a herb known popularly in Cuba as Tilo and used traditionally as sedative. The development in a solid pharmaceutical (Tablets 100 mg) using dry extract of Justicia pectolaris aqueous extract is of interest for the development of phytomedicines, which uses this active raw material. The aim of the present study was to carry out chemical and biological stability studies to the formulation. A method of coumarin determination by High Performance Liquid Chromatography (HPLC) was used and validated. The stability studies during different periods of time (24 months) showed a stability of the product stored at 32 ± 2 °C, and protected of the light.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Justicia pectoralis/pharmacognosy; Medicinal plants; Phytomedicines; Coumarins/determination; High Performance Liquid Chromatography/phytomedicines analysis; Phytomedicines/stability studies; Tilo®/tablets/stability studies.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100193
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Leaf and stem microscopic identification of Tithonia diversifolia (Hemsl.) A. Gray (Asteraceae) BJPS
Duarte,Márcia do Rocio; Empinotti,Cláudia Bonissoni.
Tithonia diversifolia (Hemsl.) A. Gray is an Asteraceae shrub, popularly known as Mexican sunflower and cultivated for ornamental and therapeutic uses in different countries. In folk medicine, it is of value for treating diabetes, malaria and infectious diseases. These indications have been corroborated by various pharmacological assays. Given the lack of data on anatomical aspects of T. diversifolia, this work aimed to investigate the leaf and stem microscopic characters of this medicinal plant and potential vegetal drug. Samples of mature leaves and young stems were sectioned and stained. Histochemical tests and scanning electron microscopy were also performed. The leaf has anomocytic stomata on both sides, dorsiventral mesophyll and several collateral...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tithonia diversifolia/pharmacognosy; Tithonia diversifolia/anatomical characters; Medicinal plants; Mexican sunflower.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100013
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Anatomical characters of the medicinal leaf and stem of Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. (Asteraceae) BJPS
Duarte,Márcia do Rocio; Silva,Ariane Gonçalves.
Gymnanthemum amygdalinum (Delile) Sch.Bip. ex Walp. (Asteraceae), better known by its former name Vernonia amygdalina Delile, is a small shrub used in folk medicine as an antipyretic, laxative, antimalarial and anthelmintic. Studies have demonstrated that different vegetal extracts possess antioxidant, antimicrobial and antiparasitic activities. Among the bioactive metabolites, there are sesquiterpene lactones, saponins, polyphenols and flavonoids. This study investigated the leaf and stem microscopic characters of G. amygdalinum, aiming to expand the knowledge on this medicinal species and indicate anatomical structures. Plant material was fixed and sectioned by freehand and using a microtome. The sections were either stained or underwent standard...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gymnanthemum amygdalinum/pharmacognosy; Gymnanthemum amygdalinum/microscopic characterization; Vernonia amygdalina/pharmacognosy; Vernonia amygdalina/microscopic characterization; Asteraceae/pharmacognosy; Medicinal plants.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400011
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Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice BJPS
Silva,Eliane Regina da; Diedrich,Denise; Bolzan,Rodrigo Cordeiro; Giacomelli,Sandro Rogério.
Medicinal plants (e.g. Discaria americana) have been used by populations for centuries. However, popular use is not enough to validate these plants as safe and effective medicinal products. The present study sought to evaluate the acute and subacute toxicity as well as the anxiolytic and antinociceptive effects of D. americana root bark and aerial parts extracts in mice. In acute toxicity studies, mice were treated with single intraperitoneal doses of the aforementioned extracts. Subacute toxicity studies were performed by oral administration of the extracts over 14 days. Anxiolytic studies consisted of the elevated plus maze method, and antinociceptive studies were based on the hot plate test. The LD50 value for D. americana aerial parts extract was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Discaria americana/phamacognosy; Medicinal plants; Discaria americana/toxicological analysis; Discaria americana/acute toxicity; Discaria americana/subacute toxicity; Discaria americana/anxiolytic effect; Discaria americana/antinociceptive effect.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200011
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In vitro cytotoxic activity of five commercial samples of Tribulus terrestris Linn in Espírito Santo (Brazil) BJPS
Oliveira Filho,Claudio Costa; Kampke,Edgar Hell; Vargas,Thais Souza; Salustriano,Nathacha Andrade; Scherer,Rodrigo; Fronza,Marcio; Campagnaro,Bianca Prandi.
ABSTRACT The objective was to investigate the total saponin and protodioscin concentrations and the cytotoxicity in vitro, of five samples of the plant Tribulus terrestris, commercially available in the metropolitan region of Vitória - Espirito Santo, Brazil, and to compare them with the aqueous extract of the plant. The chromatographic profile and quantification of protodioscin in commercial samples and plant extract were evaluated by LC-MS/MS. The percentage of total saponins were determined by the colorimetric method. Extracts and protodioscin cytotoxicity were analyzed by the MTT assay in three cell lineages: fibroblasts (L929), ovarian cancer (Ovcar3) and murine hepatoma (Hepa1c1c7). All extracts displayed high levels of total saponins (207.2 to 780.3...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tribulus terrestres/saponin/protodioscin/concentrations; Medicinal plants; Cytotoxicity/in vitro.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400622
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Beneficial effects of methanolic extract of Indigofera linnaei Ali. on the inflammatory and nociceptive responses in rodent models BJPS
Kumar,Raju Senthil; Rajkapoor,Balasubramanian; Perumal,Perumal; Kumar,Sekar Vinoth; Geetha,Arunachalam Suba.
ABSTRACT Indigofera linnaei Ali. (Tamil Name: Cheppu Nerinjil) belongs to the family Fabaceae, used for the treatment of various ailments in the traditional system of medicine. In the present study, the beneficial effects of methanol extract of whole plant of I. linnaei (MEIL) were evaluated on inflammation and nociception responses in rodent models. In vitro nitric oxide (NO), lipoxygenase (LOX) and cyclooxygense (COX) inhibitory activities were also performed to understand the mode of action. MEIL at the dose of 200 & 400 mg/kg, p.o. significantly inhibited carrageenan induced rat paw volume and reduced the weight of granuloma in cotton pellet granuloma model. The results obtained were comparable with the standard drug aceclofenac. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: IIndigofera linnaei/pharmacognosy; Indigofera linnaei/anti-inflammatory activity; Indigofera linnaei/analgesic activity; Indigofera linnaei/anti-nociceptive effect; Cyclooxygenase/inhibitors; Lipoxygenase/inhibitors; Medicinal plants.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100013
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